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Amtn Gene Detail
Summary
  • Symbol
    Amtn
  • Name
    amelotin
  • Synonyms
    5430427O21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918671
    NCBI Gene: 71421
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr5:88376108-88385916 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 43.56 cM, cytoband E2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918671
protein coding gene Chr5:88376108-88385916 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029705
protein coding gene Chr5:89389051-89398909 (+)
A/J MGP_AJ_G0029671
protein coding gene Chr5:85843513-85853321 (+)
AKR/J MGP_AKRJ_G0029617
protein coding gene Chr5:88669642-88679451 (+)
BALB/cJ MGP_BALBcJ_G0029681
protein coding gene Chr5:86751384-86761246 (+)
C3H/HeJ MGP_C3HHeJ_G0029404
protein coding gene Chr5:89034854-89044712 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030135
protein coding gene Chr5:93012448-93023435 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027371
protein coding gene Chr5:81672909-81684284 (+)
CAST/EiJ MGP_CASTEiJ_G0028814
protein coding gene Chr5:88461455-88472143 (+)
CBA/J MGP_CBAJ_G0029373
protein coding gene Chr5:96103565-96113233 (+)
DBA/2J MGP_DBA2J_G0029518
protein coding gene Chr5:85914067-85923718 (+)
FVB/NJ MGP_FVBNJ_G0029477
protein coding gene Chr5:84854555-84864363 (+)
LP/J MGP_LPJ_G0029606
protein coding gene Chr5:89776636-89786352 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029506
protein coding gene Chr5:101128657-101142241 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030169
protein coding gene Chr5:88222256-88232148 (+)
PWK/PhJ MGP_PWKPhJ_G0028533
protein coding gene Chr5:85006830-85016691 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028368
protein coding gene Chr5:87624374-87636037 (+)
WSB/EiJ MGP_WSBEiJ_G0028893
protein coding gene Chr5:88592913-88604528 (+)



Homology
more
  • Human Ortholog
    AMTN, amelotin
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AMTN, amelotin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AI3B, UNQ689
  • Links
    NCBI Gene ID: 401138
    neXtProt AC: NX_Q6UX39
    UniProt: Q6UX39

  • Chr Location
    4q13.3; chr4:70518572-70532743 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human AMTN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enamel hypomineralization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 71421 NCBI Gene Model | MGI Sequence Detail 9809 C57BL/6J ±  kb
transcript NM_027793 RefSeq | MGI Sequence Detail 1022 C57BL/6  
polypeptide Q9D3J8 UniProt | EBI | MGI Sequence Detail 213 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:237011 Nunez SM, et al., Maturation stage enamel malformations in Amtn and Klk4 null mice. Matrix Biol. 2016 May-Jul;52-54:219-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory