Dhrs2 MGI Mouse Gene Detail - MGI:1918662 - dehydrogenase/reductase member 2

Symbol

Dhrs2
Name

dehydrogenase/reductase member 2
Synonyms

5430405K24Rik, SDR family

Feature Type

protein coding gene
IDs

MGI:1918662
NCBI Gene: 71412
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr14:55459464-55478892 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.12 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

152 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918662	protein coding gene	Chr14:55459464-55478897 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021342	protein coding gene	Chr14:49230782-49248467 (+)
A/J	MGP_AJ_G0021301	protein coding gene	Chr14:48245449-48264912 (+)
AKR/J	MGP_AKRJ_G0021277	protein coding gene	Chr14:50000202-50019616 (+)
BALB/cJ	MGP_BALBcJ_G0021305	protein coding gene	Chr14:48219478-48235267 (+)
C3H/HeJ	MGP_C3HHeJ_G0021085	protein coding gene	Chr14:49692782-49712136 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021743	protein coding gene	Chr14:51722161-51738849 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019290	protein coding gene	Chr14:46644403-46659407 (+)
CAST/EiJ	MGP_CASTEiJ_G0020604	protein coding gene	Chr14:45947386-45962642 (+)
CBA/J	MGP_CBAJ_G0021052	protein coding gene	Chr14:53277893-53297270 (+)
DBA/2J	MGP_DBA2J_G0021173	protein coding gene	Chr14:47988900-48007400 (+)
FVB/NJ	MGP_FVBNJ_G0021155	protein coding gene	Chr14:47453223-47470376 (+)
LP/J	MGP_LPJ_G0021247	protein coding gene	Chr14:50283162-50298979 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021179	protein coding gene	Chr14:52636860-52653010 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021770	protein coding gene	Chr14:49181861-49198671 (+)
PWK/PhJ	MGP_PWKPhJ_G0020351	protein coding gene	Chr14:44525045-44541584 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020179	protein coding gene	Chr14:45177209-45192263 (+)
WSB/EiJ	MGP_WSBEiJ_G0020657	protein coding gene	Chr14:49477901-49494475 (+)

Human Ortholog

DHRS2, dehydrogenase/reductase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DHRS2, dehydrogenase/reductase 2
Synonyms

HEP27, SDR25C1
Links

HGNC:18349

NCBI Gene ID: 10202

neXtProt AC: NX_Q13268

UniProt: Q13268
Chr Location

14q11.2; chr14:23630115-23645639 (+) GRCh38

MGI Vertebrate Homology

Dhrs2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DHRS2
Gene Tree

Dhrs2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

1 involving Dhrs2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

2
cDNA Data

4
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

6
UniProt

2
CCDS

CCDS27110.1

Ensembl

ENSMUSG00000022209 (Evidence)
NCBI Gene

71412

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022209	Ensembl Gene Model \| MGI Sequence Detail	19429	C57BL/6J	± kb
transcript	ENSMUST00000165432	Ensembl \| MGI Sequence Detail	849	Not Applicable
polypeptide	ENSMUSP00000129115	Ensembl \| MGI Sequence Detail	282	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR020904 Short-chain dehydrogenase/reductase, conserved site

IPR002347 Short-chain dehydrogenase/reductase SDR

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All nucleic 4

cDNA 4

Microarray probesets 2

Summaries

All 27

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194

TSS for Dhrs2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125752	Chr14:55459462-55459466 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23