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Chd6 Gene Detail
Summary
  • Symbol
    Chd6
  • Name
    chromodomain helicase DNA binding protein 6
  • Synonyms
    5430439G14Rik, 6330406J24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918639
    NCBI Gene: 71389
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:160946978-161109075 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 80.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    439 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918639
protein coding gene Chr2:160946978-161109086 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026810
protein coding gene Chr2:166153501-166321828 (-)
A/J MGP_AJ_G0026776
protein coding gene Chr2:159474439-159640795 (-)
AKR/J MGP_AKRJ_G0026747
protein coding gene Chr2:164193627-164364819 (-)
BALB/cJ MGP_BALBcJ_G0026785
protein coding gene Chr2:159788288-159954760 (-)
C3H/HeJ MGP_C3HHeJ_G0026527
protein coding gene Chr2:164525090-164691016 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027234
protein coding gene Chr2:171063023-171233811 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024604
protein coding gene Chr2:152848165-153006883 (-)
CAST/EiJ MGP_CASTEiJ_G0025989
protein coding gene Chr2:164907385-165078417 (-)
CBA/J MGP_CBAJ_G0026504
protein coding gene Chr2:177227038-177402800 (-)
DBA/2J MGP_DBA2J_G0026642
protein coding gene Chr2:158649485-158820667 (-)
FVB/NJ MGP_FVBNJ_G0026609
protein coding gene Chr2:157055763-157216462 (-)
LP/J MGP_LPJ_G0026745
protein coding gene Chr2:166256315-166431426 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026630
protein coding gene Chr2:180926282-181115174 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027290
protein coding gene Chr2:164030391-164198718 (-)
PWK/PhJ MGP_PWKPhJ_G0025723
protein coding gene Chr2:158200773-158367643 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025526
protein coding gene Chr2:162909091-163072292 (-)
WSB/EiJ MGP_WSBEiJ_G0026059
protein coding gene Chr2:164920196-165088439 (-)



Homology
more
  • Human Ortholog
    CHD6, chromodomain helicase DNA binding protein 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHD6, chromodomain helicase DNA binding protein 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHD5, CHD-6, RIGB
  • Links
    NCBI Gene ID: 84181
    neXtProt AC: NX_Q8TD26
    UniProt: Q8TD26

  • Chr Location
    20q12; chr20:41402101-41618494 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32772
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CHD6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired coordination that is not due to muscle weakness or bradykinesia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057133 Ensembl Gene Model | MGI Sequence Detail 162098 C57BL/6J ±  kb
transcript ENSMUST00000039782 Ensembl | MGI Sequence Detail 10515 Not Applicable  
polypeptide ENSMUSP00000042291 Ensembl | MGI Sequence Detail 2711 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 118
    cDNA 118

    Microarray probesets 3
Other
Accession IDs
less
MGI:1921259
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:203994 Wiszniak S, et al., The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties. Dev Biol. 2013 Nov 15;383(2):186-200

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory