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Chd6
Gene Detail
Symbol

Name
ID
Chd6
chromodomain helicase DNA binding protein 6
MGI:1918639
Synonyms
5430439G14Rik, 6330406J24Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
80.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:160946978-161109075 bp, - strand
From VEGA annotation of GRCm38

  162098 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32772  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CHD6
Gene Tree: Chd6

Human
homologs
CHD6, chromodomain helicase DNA binding protein 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 84181
neXtProt AC: NX_Q8TD26

Human Synonyms: CHD5, CHD-6, RIGB

Human Chr (Location): 20q12; chr20:41402101-41618494 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(36) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display impaired coordination that is not due to muscle weakness or bradykinesia.
 
Interactions
Chd6 interacts with 415 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (3 records)
cDNA source data(116)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase chd6    NEW 
Molecular
reagents
All nucleic(116) cDNA(116)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000001051 (Evidence)
Ensembl Gene Model ENSMUSG00000057133 (Evidence)
Entrez Gene 71389 (Evidence)
UniGene 122738
DFCI TC1597867, TC1597187, TC1593044, TC1585005, TC1632238, TC1628643, TC1612666, TC1632855, TC1637814
DoTS DT.94261442, DT.91426750, DT.91354235, DT.110675269, DT.101238635, DT.91300502, DT.532500, DT.94295749, DT.99847873
NIA Mouse Gene Index U023604
EC 3.6.4.12
Consensus CDS Project CCDS17000.1
International Mouse Phenotyping Consortium Status Chd6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001051 VEGA Gene Model | MGI Sequence Detail 162098 C57BL/6J ±  kb
transcript OTTMUST00000038183 VEGA | MGI Sequence Detail 10515 Not Applicable 
polypeptide OTTMUSP00000017124 VEGA | MGI Sequence Detail 2711 Not Applicable 

For the selected sequences
All sequences(109) RefSeq(18) UniProt(9)
Polymorphisms
SNPs within 2kb(440 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006576 BRK domain
InterPro IPR023780 Chromo domain
InterPro IPR016197 Chromo domain-like
InterPro IPR000953 Chromo domain/shadow
InterPro IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001005 SANT/Myb domain
InterPro IPR000330 SNF2-related
Protein Ontology PR:000005412 chromodomain-helicase-DNA-binding protein 6
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203994 Wiszniak S, et al., The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties. Dev Biol. 2013 Nov 15;383(2):186-200
All references(38)
Other
accession IDs
MGI:1921259

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory