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Pex1
Gene Detail
Symbol

Name
ID
Pex1
peroxisomal biogenesis factor 1
MGI:1918632
Synonyms
5430414H02Rik, E330005K07Rik, peroxisome biogenesis factor 1, ZWS1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
2.26 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:3596066-3637232 bp, + strand
From VEGA annotation of GRCm38

  41167 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27006  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pex1

Human
homologs
Human Homolog PEX1, peroxisomal biogenesis factor 1
NCBI Gene ID 5189
neXtProt AC  NX_O43933
Human Synonyms  PBD1A, PBD1B, ZWS, ZWS1
Human Chr (Location)  7q21.2; chr7:92487020-92528531 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human PEX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Human Diseases Modeled Using Mouse Pex1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Pex1 interacts with 74 markers (Mir18, Mir18b, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process ATP catabolic process, microtubule-based peroxisome localization, ...
Component cytoplasm, cytosol, ...
Function ATPase activity, coupled, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(10)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000028545 (Evidence)
Ensembl Gene ModelENSMUSG00000005907 (Evidence)
Entrez Gene71382 (Evidence)
NIA Mouse Gene IndexU025929
PDB1WLF
Consensus CDS ProjectCCDS19065.1
International Mouse Knockout Project StatusPex1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028545 VEGA Gene Model | MGI Sequence Detail 41167 C57BL/6J ±  kb
transcript OTTMUST00000070783 VEGA | MGI Sequence Detail 4555 Not Applicable 
polypeptide OTTMUSP00000036123 VEGA | MGI Sequence Detail 1284 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(11) UniProt(11)
Polymorphisms
SNPs within 2kb(187 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR009010 Aspartate decarboxylase-like domain
InterPro IPR003960 ATPase, AAA-type, conserved site
InterPro IPR003959 ATPase, AAA-type, core
InterPro IPR025653 Peroxisome biogenesis factor 1
InterPro IPR015343 Peroxisome biogenesis factor 1, alpha/beta
InterPro IPR015342 Peroxisome biogenesis factor 1, N-terminal
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000012553 peroxisome biogenesis factor 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210296 Hiebler S, et al., The Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder. Mol Genet Metab. 2014 Apr;111(4):522-32
All references(35)
Disease annotation references (1)
Other
accession IDs
MGI:2444380

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory