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Treml1
Gene Detail
 Symbol
Name
ID
Treml1
triggering receptor expressed on myeloid cells-like 1
MGI:1918576
Synonyms 5430401J17Rik, TLT-1
Feature Type protein coding gene
Genetic Map
Chromosome 17
23.99 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:48359916-48367146 bp, + strand
From NCBI annotation of GRCm38

  7231 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52257  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Treml1

Human
homologs
Human Homolog TREML1, triggering receptor expressed on myeloid cells-like 1
NCBI Gene ID 340205
neXtProt AC  NX_Q86YW5
Human Synonyms  dJ238O23.3, GLTL1825, PRO3438, TLT1, TLT-1
Human Chr (Location)  6p21.1; chr6:41149260-41154349 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show a reduced platelet count, defective platelet aggregation, prolonged bleeding times, enhanced inflammatory hemorrhage, and increased susceptibility to death from endotoxin (LPS) challenge.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process calcium-mediated signaling, negative regulation of signal transduction, ...
Component cell surface, cytoplasm, ...
Function protein binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (21)    Tissues (1)    Images (21)
Theiler Stages: 23
Assay TypeResults
RNA in situ 21
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000023993 (Evidence)
Entrez Gene71326 (Evidence)
UniGene90177
DFCITC1586936
DoTSDT.40143935
NIA Mouse Gene IndexU018078
Consensus CDS ProjectCCDS28866.1
International Mouse Knockout Project StatusTreml1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 71326 NCBI Gene Model | MGI Sequence Detail 7231 C57BL/6J ±  kb
transcript NM_027763 RefSeq | MGI Sequence Detail 1256 C57BL/6 
polypeptide Q8K558 UniProt | EBI | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(9) UniProt(5)
Polymorphisms SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000016627 trem-like transcript 1 protein
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:192976 Yoon SH, et al., TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis. J Biol Chem. 2012 Aug 24;287(35):29620-6
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory