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Treml1
Gene Detail
Symbol

Name
ID
Treml1
triggering receptor expressed on myeloid cells-like 1
MGI:1918576
Synonyms
5430401J17Rik, TLT-1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
23.99 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:48359916-48367174 bp, + strand
From Ensembl annotation of GRCm38

  7259 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52257  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TREML1
Gene Tree: Treml1

Human
homologs
TREML1, triggering receptor expressed on myeloid cells-like 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 340205
neXtProt AC: NX_Q86YW5

Human Synonyms: dJ238O23.3, GLTL1825, PRO3438, TLT1, TLT-1

Human Chr (Location): 6p21.1; chr6:41149260-41154349 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show a reduced platelet count, defective platelet aggregation, prolonged bleeding times, enhanced inflammatory hemorrhage, and increased susceptibility to death from endotoxin (LPS) challenge.
 
Interactions
Treml1 interacts with 47 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process calcium-mediated signaling, negative regulation of signal transduction, ...
Component cell surface, cytoplasm, ...
Function protein binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (21)    Tissues (1)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000023993 (Evidence)
Entrez Gene 71326 (Evidence)
UniGene 90177
DFCI TC1586936
DoTS DT.40143935
NIA Mouse Gene Index U018078
Consensus CDS Project CCDS28866.1
International Mouse Phenotyping Consortium Status Treml1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023993 Ensembl Gene Model | MGI Sequence Detail 7259 C57BL/6J ±  kb
transcript ENSMUST00000024792 Ensembl | MGI Sequence Detail 1248 Not Applicable 
polypeptide ENSMUSP00000024792 Ensembl | MGI Sequence Detail 322 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(7) UniProt(5)
Polymorphisms
SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000016627 trem-like transcript 1 protein
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:192976 Yoon SH, et al., TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis. J Biol Chem. 2012 Aug 24;287(35):29620-6
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory