Rassf8 MGI Mouse Gene Detail - MGI:1918573 - Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

Symbol

Rassf8
Name

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Synonyms

5133400D11Rik, mHoj-1

Feature Type

protein coding gene
IDs

MGI:1918573
NCBI Gene: 71323
Gene Overview

MyGene.info: RASSF8
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:145746748-145821079 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 77.68 cM, cytoband G3
Mapping Data

3 experiments

SNPs within 2kb

929 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918573	protein coding gene	Chr6:145746562-145821079 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0031482	protein coding gene	Chr6:150770179-150847820 (+)
A/J	MGP_AJ_G0031457	protein coding gene	Chr6:144797904-144873018 (+)
AKR/J	MGP_AKRJ_G0031385	protein coding gene	Chr6:149098246-149185350 (+)
BALB/cJ	MGP_BALBcJ_G0031465	protein coding gene	Chr6:144552447-144625586 (+)
C3H/HeJ	MGP_C3HHeJ_G0031186	protein coding gene	Chr6:149144751-149230860 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031926	protein coding gene	Chr6:154821736-154902500 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029050	protein coding gene	Chr6:143544483-143616217 (+)
CAST/EiJ	MGP_CASTEiJ_G0030554	protein coding gene	Chr6:148786484-148863328 (+)
CBA/J	MGP_CBAJ_G0031146	protein coding gene	Chr6:160697618-160777302 (+)
DBA/2J	MGP_DBA2J_G0031302	protein coding gene	Chr6:143589318-143662461 (+)
FVB/NJ	MGP_FVBNJ_G0031254	protein coding gene	Chr6:142319095-142390828 (+)
LP/J	MGP_LPJ_G0031387	protein coding gene	Chr6:150872109-150946048 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031294	protein coding gene	Chr6:164476233-164555994 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031959	protein coding gene	Chr6:148928758-149014276 (+)
PWK/PhJ	MGP_PWKPhJ_G0030281	protein coding gene	Chr6:142095174-142167999 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030105	protein coding gene	Chr6:147090824-147167811 (+)
WSB/EiJ	MGP_WSBEiJ_G0030647	protein coding gene	Chr6:149550032-149628925 (+)

Human Ortholog

RASSF8, Ras association domain family member 8

Vertebrate Orthologs

10

Human Ortholog

RASSF8, Ras association domain family member 8
Orthology source: HomoloGene, HGNC
Synonyms

C12orf2, HOJ1
Links

HGNC:13232

NCBI Gene ID: 11228

neXtProt AC: NX_Q8NHQ8

UniProt: Q8NHQ8
Chr Location

12p12.1; chr12:25959031-26079892 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 5219
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: RASSF8
Gene Tree

Rassf8

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

5
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

2
GO References

1

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

97
Tissues

45
cDNA Data

9
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rassf8

ZFIN rassf8b

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Rassf8 interacts with 418 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

52
RefSeq

6
UniProt

4
CCDS

CCDS20696.1

Ensembl

ENSMUSG00000030259 (Evidence)
NCBI Gene

71323

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030259	Ensembl Gene Model \| MGI Sequence Detail	74332	C57BL/6J	± kb
transcript	ENSMUST00000111704	Ensembl \| MGI Sequence Detail	5446	Not Applicable
polypeptide	ENSMUSP00000107333	Ensembl \| MGI Sequence Detail	419	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031357 ras association domain-containing protein 8

(term hierarchy)
InterPro Domains

IPR033593 N-terminal RASSF family

IPR000159 Ras-associating (RA) domain

IPR033632 Ras association domain-containing protein 8

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 9

cDNA 9

Microarray probesets 7

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MGI:2141651, MGI:3034889

Summaries

All 37

Developmental Gene Expression 5

Gene Ontology 1

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

TSS for Rassf8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59553	Chr6:145746585-145746606 (+)	-152 bp
Tssr59554	Chr6:145746739-145746767 (+)	5 bp
Tssr59555	Chr6:145746779-145746808 (+)	46 bp
Tssr59556	Chr6:145746839-145746869 (+)	106 bp
Tssr59558	Chr6:145808189-145808224 (+)	61,459 bp
Tssr59559	Chr6:145815390-145815423 (+)	68,659 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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