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Arhgap26
Gene Detail
Symbol

Name
ID
Arhgap26
Rho GTPase activating protein 26
MGI:1918552
Synonyms
1810044B20Rik, 2610010G17Rik, 4933432P15Rik, mKIAA0621
Feature Type
protein coding gene
Genetic Map
Chromosome 18
20.51 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:38601534-39376284 bp, + strand
From VEGA annotation of GRCm38

  774751 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36349  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: ARHGAP26
Protein SuperFamily: Rho GTPase-activating protein, Oligophrenin 1/Graf types
Gene Tree: Arhgap26

Human
homologs
ARHGAP26, Rho GTPase activating protein 26
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23092
neXtProt AC: NX_Q9UNA1

Human Synonyms: GRAF, GRAF1, OPHN1L, OPHN1L1

Human Chr (Location): 5q31; chr5:142770380-143229007 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ARHGAP26

Mutations,
alleles, and
phenotypes
All mutations/alleles(137) : Gene trapped(134) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Arhgap26 interacts with 430 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process actin cytoskeleton organization, plasma membrane organization, ...
Component cell junction, cytoplasm, ...
Function GTPase activator activity, phospholipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (5)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ARHGAP26 ; Xenbase arhgap26    NEW 
Molecular
reagents
All nucleic(40) cDNA(40)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000020314 (Evidence)
Ensembl Gene Model ENSMUSG00000036452 (Evidence)
Entrez Gene 71302 (Evidence)
UniGene 329396
DFCI TC1640293, TC1639922, TC1591357, TC1622875, TC1585958, TC1601980
DoTS DT.101351422, DT.40181046, DT.91331633, DT.55122533, DT.55232876, DT.55182114
NIA Mouse Gene Index U043670
Consensus CDS Project CCDS29205.1
International Mouse Phenotyping Consortium Status Arhgap26
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020314 VEGA Gene Model | MGI Sequence Detail 774751 C57BL/6J ±  kb
transcript OTTMUST00000048196 VEGA | MGI Sequence Detail 7898 Not Applicable 
polypeptide OTTMUSP00000022023 VEGA | MGI Sequence Detail 814 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(10) UniProt(12)
Polymorphisms
SNPs within 2kb(5916 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5926)
Protein-related
information
ResourceIDDescription
InterPro IPR013606 IRSp53/MIM homology domain (IMD)
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000004232 rho GTPase-activating protein 26
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:215392 Lenhart KC, et al., GRAF1 promotes ferlin-dependent myoblast fusion. Dev Biol. 2014 Sep 15;393(2):298-311
All references(38)
Other
accession IDs
MGI:1917050, MGI:1917571, MGI:2147280

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory