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Slc29a3
Gene Detail
Symbol

Name
ID
Slc29a3
solute carrier family 29 (nucleoside transporters), member 3
MGI:1918529
Synonyms
4933435C21Rik, Ent3
Feature Type
protein coding gene
Genetic Map
Chromosome 10
31.38 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:60712072-60752794 bp, - strand
From VEGA annotation of GRCm38

  40723 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56805  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC29A3
Protein SuperFamily: ENT
Gene Tree: Slc29a3

Human
homologs
SLC29A3, solute carrier family 29 (equilibrative nucleoside transporter), member 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 55315
neXtProt AC: NX_Q9BZD2

Human Synonyms: ENT3, HCLAP, HJCD, PHID

Human Chr (Location): 10q22.1; chr10:71319253-71363396 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC29A3

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit lymphadenopathy, splenomegaly, histiocytic sarcoma, and premature death associated with extramedullary hematopoiesis, increased macrophage proliferation and apoptosis and abnormal lysosome function.
 
Interactions
Slc29a3 interacts with 264 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process nucleoside transmembrane transport, nucleoside transport, ...
Component endosome, integral component of membrane, ...
Function nucleoside transmembrane transporter activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc29a3    NEW 
Molecular
reagents
All nucleic(44) cDNA(43) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000030007 (Evidence)
Ensembl Gene Model ENSMUSG00000020100 (Evidence)
Entrez Gene 71279 (Evidence)
UniGene 284462
DFCI TC1636326, TC1633911, TC1582150
DoTS DT.94196773, DT.91339765, DT.55234151, DT.94196774, DT.94246171
NIA Mouse Gene Index U031831
Consensus CDS Project CCDS48571.1
International Mouse Phenotyping Consortium Status Slc29a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030007 VEGA Gene Model | MGI Sequence Detail 40723 C57BL/6J ±  kb
transcript OTTMUST00000074413 VEGA | MGI Sequence Detail 5240 Not Applicable 
polypeptide OTTMUSP00000038735 VEGA | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(302 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002259 Equilibrative nucleoside transporter
Protein Ontology PR:000015056 equilibrative nucleoside transporter 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188342 Campeau PM, et al., Whole-exome sequencing identifies mutations in the nucleoside transporter gene SLC29A3 in dysosteosclerosis, a form of osteopetrosis. Hum Mol Genet. 2012 Nov 15;21(22):4904-9
All references(39)
Other
accession IDs
MGI:3035493

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory