Slc29a3
Gene Detail

Symbol Name ID

Slc29a3 solute carrier family 29 (nucleoside transporters), member 3 MGI:1918529

Synonyms

4933435C21Rik, Ent3

Feature Type

protein coding gene

Genetic Map

Chromosome 10

31.38 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:60712072-60752794 bp, - strand From VEGA annotation of GRCm38   40723 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56805  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ENT
Gene Tree: Slc29a3

Human homologs

Human Homolog		SLC29A3, solute carrier family 29 (nucleoside transporters), member 3
NCBI Gene ID		55315
neXtProt AC		NX_Q9BZD2
Human Synonyms		ENT3, HCLAP, HJCD, PHID
Human Chr (Location)		10q22.1; chr10:73079010-73123147 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC29A3

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit lymphadenopathy, splenomegaly, histiocytic sarcoma, and premature death associated with extramedullary hematopoiesis, increased macrophage proliferation and apoptosis and abnormal lysosome function.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	nucleoside transport, transport
Component	endosome, integral to membrane, ...
Function	nucleoside transmembrane transporter activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23

Assay Type	Results
RNA in situ	1

cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) cDNA(43) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000030007 (Evidence)
Ensembl Gene Model	ENSMUSG00000020100 (Evidence)
Entrez Gene	71279 (Evidence)
UniGene	284462
DFCI	TC1582150, TC1633911, TC1636326
DoTS	DT.55234151, DT.91339765, DT.94196773, DT.94196774, DT.94246171
NIA Mouse Gene Index	U031831
Consensus CDS Project	CCDS48571.1
International Mouse Knockout Project Status	Slc29a3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030007	VEGA Gene Model | MGI Sequence Detail	40723	C57BL/6J
transcript	OTTMUST00000074413	VEGA | MGI Sequence Detail	5240	Not Applicable
polypeptide	OTTMUSP00000038735	VEGA | MGI Sequence Detail	475	Not Applicable

All sequences(47) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(180 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002259	Equilibrative nucleoside transporter
Protein Ontology	PR:000015056	equilibrative nucleoside transporter 3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188342 Campeau PM, et al., Whole-exome sequencing identifies mutations in the nucleoside transporter gene SLC29A3 in dysosteosclerosis, a form of osteopetrosis. Hum Mol Genet. 2012 Nov 15;21(22):4904-9
All references(39)

Other accession IDs

MGI:3035493