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Dym
Gene Detail
Symbol

Name
ID
Dym
dymeclin
MGI:1918480
Synonyms
1810041M12Rik, 4933427L07Rik, C030019K18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 18
50.97 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:75018772-75286966 bp, + strand
From NCBI annotation of GRCm38

  268195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69237  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dym

Human
homologs
Human Homolog DYM, dymeclin
NCBI Gene ID 54808
neXtProt AC  NX_Q7RTS9
Human Synonyms  DMC, SMC
Human Chr (Location)  18q21.1; chr18:49043026-49460709 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human DYM
Mutations,
alleles, and
phenotypes
All mutations/alleles(141) : Gene trapped(141)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele display decreased body size with short tubular bones, chondrodysplasia, partial penetrance of obstructive hydronephrosis and impaired vesicular transport.
 
Human Diseases Modeled Using Mouse Dym (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Dym interacts with 45 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process bone development, Golgi organization
Component cytoplasm, Golgi apparatus
Function enzyme binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (4)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 8
cDNA source data(84)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(89) cDNA(89)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000035765 (Evidence)
Entrez Gene69190 (Evidence)
UniGene173826
DFCITC1574169, TC1717409, TC1748547
DoTSDT.101710434, DT.110761064, DT.491544, DT.529079, DT.91281341, DT.91328951, DT.99860274
NIA Mouse Gene IndexU018901
Consensus CDS ProjectCCDS29346.1
International Mouse Knockout Project StatusDym
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 69190 NCBI Gene Model | MGI Sequence Detail 268195 C57BL/6J ±  kb
transcript NM_027727 RefSeq | MGI Sequence Detail 2471 C57BL/6 
polypeptide Q8CHY3 UniProt | EBI | MGI Sequence Detail 669 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(11) UniProt(1)
Polymorphisms
SNPs within 2kb(2371 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR019142 Dymeclin
Protein Ontology PR:000006769 dymeclin
Graphical View of Protein Domain Structure
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(33)
Disease annotation references (1)
Other
accession IDs
MGI:1916440, MGI:1924708

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory