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Dym
Gene Detail
Symbol

Name
ID
Dym
dymeclin
MGI:1918480
Synonyms
1810041M12Rik, 4933427L07Rik, C030019K18Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 18
50.97 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:75018772-75286966 bp, + strand
From Ensembl annotation of GRCm38

  268195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69237  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DYM
Gene Tree: Dym

Human
homologs
DYM, dymeclin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 54808
neXtProt AC: NX_Q7RTS9

Human Synonyms: DMC, SMC

Human Chr (Location): 18q21.1; chr18:49041474-49460709 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human DYM

Mutations,
alleles, and
phenotypes
All mutations/alleles(141) : Gene trapped(141)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trapped allele display decreased body size with short tubular bones, chondrodysplasia, partial penetrance of obstructive hydronephrosis and impaired vesicular transport.
 
Human Diseases Modeled in Mice Using Dym (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Dym interacts with 44 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process bone development, Golgi organization
Component cytoplasm, Golgi apparatus
Function enzyme binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (4)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 8
cDNA source data(84)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dym    NEW 
Molecular
reagents
All nucleic(89) cDNA(89)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000035765 (Evidence)
Entrez Gene 69190 (Evidence)
UniGene 173826
DFCI TC1748547, TC1717409, TC1574169
DoTS DT.110761064, DT.101710434, DT.491544, DT.91328951, DT.91281341, DT.529079, DT.99860274
NIA Mouse Gene Index U018901
Consensus CDS Project CCDS29346.1
International Mouse Phenotyping Consortium Status Dym
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035765 Ensembl Gene Model | MGI Sequence Detail 268195 C57BL/6J ±  kb
transcript ENSMUST00000039608 Ensembl | MGI Sequence Detail 2471 Not Applicable 
polypeptide ENSMUSP00000047054 Ensembl | MGI Sequence Detail 669 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(11) UniProt(1)
Polymorphisms
SNPs within 2kb(2371 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR019142 Dymeclin
Protein Ontology PR:000006769 dymeclin
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(32)
Disease annotation references (1)
Other
accession IDs
MGI:1916440, MGI:1924708

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory