Dym
Gene Detail

Symbol Name ID

Dym dymeclin MGI:1918480

Synonyms

1810041M12Rik, 4933427L07Rik, C030019K18Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 18

50.97 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:75018772-75286966 bp, + strand From NCBI annotation of GRCm38   268195 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69237  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dym

Human homologs

Human Homolog		DYM, dymeclin
NCBI Gene ID		54808
neXtProt AC		NX_Q7RTS9
Human Synonyms		DMC, SMC
Human Chr (Location)		18q21.1; chr18:46570172-46987079 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human DYM

Alleles and phenotypes

All alleles(141) : Gene trapped(141)
 

Mice homozygous for a gene trapped allele display decreased body size with short tubular bones, chondrodysplasia, partial penetrance of obstructive hydronephrosis and impaired vesicular transport.

 
Human Diseases Modeled Using Mouse Dym (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	bone development, Golgi organization
Component	cytoplasm, Golgi apparatus, ...
Function	enzyme binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (3)    Images (9)
Theiler Stages: 28

Assay Type	Results
RNA in situ	8

cDNA source data(84)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(89) cDNA(89)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000035765 (Evidence)
Entrez Gene	69190 (Evidence)
UniGene	173826
DFCI	TC1574169, TC1717409, TC1748547
DoTS	DT.101710434, DT.110761064, DT.491544, DT.529079, DT.91281341, DT.91328951, DT.99860274
NIA Mouse Gene Index	U018901
Consensus CDS Project	CCDS29346.1
International Mouse Knockout Project Status	Dym

Sequences

Length	Strain/Species
genomic	69190	NCBI Gene Model | MGI Sequence Detail	268195	C57BL/6J
transcript	NM_027727	RefSeq | MGI Sequence Detail	2471	C57BL/6
polypeptide	Q8CHY3	UniProt | EBI | MGI Sequence Detail	669	Not Applicable

All sequences(38) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(1914 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019142	Dymeclin
Protein Ontology	PR:000006769	dymeclin

Graphical View of Protein Domain Structure

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(33)

Other accession IDs

MGI:1916440, MGI:1924708