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Ppm1f
Gene Detail
 Symbol
Name
ID
Ppm1f
protein phosphatase 1F (PP2C domain containing)
MGI:1918464
Synonyms 1110021B16Rik, 4933427B07Rik, MGC:25978, mKIAA0015
Feature Type protein coding gene
Genetic Map
Chromosome 16
10.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:16896469-16927364 bp, + strand
From VEGA annotation of GRCm38

  30896 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22828  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ppm1f

Human
homologs
Human Homolog PPM1F, protein phosphatase, Mg2+/Mn2+ dependent, 1F
NCBI Gene ID 9647
neXtProt AC  NX_P49593
Human Synonyms  CAMKP, CaMKPase, FEM-2, hFEM-2, POPX2
Human Chr (Location)  22q11.22; chr22:21919419-21952878 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(23) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation are not detected at weaning. Mice heterozygous for a targeted mutation display hyperactivity and an increase in pain threshold.
 
Interactions
Ppm1f interacts with 335 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process apoptotic process, cellular response to drug, ...
Component cytosol, perinuclear region of cytoplasm, ...
Function calmodulin-dependent protein phosphatase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (454)    Tissues (115)    Images (98)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 335
In situ reporter (knock in) 81
RT-PCR 38
cDNA source data(94)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000023702 (Evidence)
Ensembl Gene ModelENSMUSG00000026181 (Evidence)
Entrez Gene68606 (Evidence)
UniGene230296
DFCITC1598886
DoTSDT.491599
NIA Mouse Gene IndexU016857
EC3.1.3.16
Consensus CDS ProjectCCDS27991.1
International Mouse Knockout Project StatusPpm1f
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023702 VEGA Gene Model | MGI Sequence Detail 30896 C57BL/6J ±  kb
transcript OTTMUST00000057880 VEGA | MGI Sequence Detail 4922 Not Applicable 
polypeptide OTTMUSP00000027985 VEGA | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015655 Protein phosphatase 2C
InterPro IPR000222 Protein phosphatase 2C, manganese/magnesium aspartate binding site
InterPro IPR001932 Protein phosphatase 2C (PP2C)-like
Protein Ontology PR:000013094 protein phosphatase 1F
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)
Other
accession IDs
MGI:1915856

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory