Ppm1f
Gene Detail

Symbol Name ID

Ppm1f protein phosphatase 1F (PP2C domain containing) MGI:1918464

Synonyms

1110021B16Rik, 4933427B07Rik, MGC:25978, mKIAA0015

Feature Type

protein coding gene

Genetic Map

Chromosome 16

10.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:16896469-16927364 bp, + strand From VEGA annotation of GRCm38   30896 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ppm1f ± 2 cM)

Gene Tree: Ppm1f

Human ortholog

PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F NCBI Gene ID 9647
Human Synonyms: CAMKP, CaMKPase, FEM-2, hFEM-2, POPX2
Human Chr22:22273792-22307250 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(26) : Targeted(3) Gene trapped(23)
 

Mice homozygous for a targeted mutation are not detected at weaning. Mice heterozygous for a targeted mutation display hyperactivity and an increase in pain threshold.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	apoptotic process, cellular response to drug, ...
Component	cytosol, perinuclear region of cytoplasm, ...
Function	calmodulin-dependent protein phosphatase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (454)    Tissues (115)    Images (98)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	335
In situ reporter (knock in)	81
RT-PCR	38

cDNA source data(94)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000023702 (Evidence)
Ensembl Gene Model	ENSMUSG00000026181 (Evidence)
Entrez Gene	68606 (Evidence)
UniGene	230296
DFCI	TC1598886
DoTS	DT.491599
NIA Mouse Gene Index	U016857
EC	3.1.3.16
Consensus CDS Project	CCDS27991.1
International Mouse Knockout Project Status	Ppm1f

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023702	VEGA Gene Model | MGI Sequence Detail	30896	C57BL/6J
transcript	OTTMUST00000057880	VEGA | MGI Sequence Detail	4922	Not Applicable
polypeptide	OTTMUSP00000027985	VEGA | MGI Sequence Detail	452	Not Applicable

All sequences(30) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(93 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015655	Protein phosphatase 2C
InterPro	IPR001932	Protein phosphatase 2C-like
InterPro	IPR000222	Protein phosphatase 2C, manganese/magnesium aspartate binding site
Protein Ontology	PR:000013094	protein phosphatase 1F

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)

Other accession IDs

MGI:1915856