About   Help   FAQ
Ppm1f Gene Detail
Summary
  • Symbol
    Ppm1f
  • Name
    protein phosphatase 1F (PP2C domain containing)
  • Synonyms
    1110021B16Rik, 4933427B07Rik, MGC:25978, mKIAA0015
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918464
    NCBI Gene: 68606
  • Gene Overview
    MyGene.info: PPM1F
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:16896469-16927364 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918464
protein coding gene Chr16:16896469-16927375 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022565
protein coding gene Chr16:13990494-14025171 (+)
A/J MGP_AJ_G0022526
protein coding gene Chr16:13306749-13337637 (+)
AKR/J MGP_AKRJ_G0022503
protein coding gene Chr16:13849160-13880900 (+)
BALB/cJ MGP_BALBcJ_G0022529
protein coding gene Chr16:13458817-13489687 (+)
C3H/HeJ MGP_C3HHeJ_G0022296
protein coding gene Chr16:13956672-13990255 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022980
protein coding gene Chr16:14211183-14242566 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020500
protein coding gene Chr16:13390606-13420990 (+)
CAST/EiJ MGP_CASTEiJ_G0021824
protein coding gene Chr16:13885953-13918479 (+)
CBA/J MGP_CBAJ_G0022267
protein coding gene Chr16:14877987-14908899 (+)
DBA/2J MGP_DBA2J_G0022397
protein coding gene Chr16:13245279-13276217 (+)
FVB/NJ MGP_FVBNJ_G0022373
protein coding gene Chr16:13267932-13299441 (+)
LP/J MGP_LPJ_G0022464
protein coding gene Chr16:13779149-13810471 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022394
protein coding gene Chr16:14582179-14614130 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022991
protein coding gene Chr16:13759098-13790023 (+)
PWK/PhJ MGP_PWKPhJ_G0021567
protein coding gene Chr16:13484465-13516324 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021395
protein coding gene Chr16:13766160-13796227 (+)
WSB/EiJ MGP_WSBEiJ_G0021871
protein coding gene Chr16:13768781-13802508 (+)



Homology
more
  • Human Ortholog
    PPM1F, protein phosphatase, Mg2+/Mn2+ dependent 1F
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPM1F, protein phosphatase, Mg2+/Mn2+ dependent 1F
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAMKP, CaMKPase, FEM-2, hFEM-2, POPX2
  • Links
    NCBI Gene ID: 9647
    neXtProt AC: NX_P49593
    UniProt: P49593

  • Chr Location
    22q11.22; chr22:21919419-21952878 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 22828
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PPM1F
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation are not detected at weaning. Mice heterozygous for a targeted mutation display hyperactivity and an increase in pain threshold.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026181 Ensembl Gene Model | MGI Sequence Detail 30896 C57BL/6J ±  kb
transcript ENSMUST00000027373 Ensembl | MGI Sequence Detail 4922 Not Applicable  
polypeptide ENSMUSP00000027373 Ensembl | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 96
    cDNA 95
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1915856
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/11/2018
MGI 6.13
The Jackson Laboratory