Dydc2 MGI Mouse Gene Detail - MGI:1918450 - DPY30 domain containing 2

Symbol

Dydc2
Name

DPY30 domain containing 2
Synonyms

4933428D01Rik

Feature Type

protein coding gene
IDs

MGI:1918450
NCBI Gene: 71200
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr14:40771074-40791165 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 22.36 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

428 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918450	protein coding gene	Chr14:40770573-40795014 (-)
129S1/SvImJ	ENSMUSG00200015487	protein coding gene	Chr14:32672744-32692838 (-)
A/J	ENSMUSG00195020289	protein coding gene	Chr14:33679269-33699362 (-)
AKR/J	ENSMUSG00220038039	protein coding gene	Chr14:32831313-32851405 (-)
BALB/cJ	ENSMUSG00180041342	protein coding gene	Chr14:32763370-32783465 (-)
C3H/HeJ	ENSMUSG00175026818	protein coding gene	Chr14:32847310-32867404 (-)
C57BL/6NJ	ENSMUSG00215016176	protein coding gene	Chr14:33082934-33103030 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019140	protein coding gene	Chr14:32967174-32978464 (-)
CAST/EiJ	ENSTCUG00005009898	protein coding gene	Chr14:32775464-32787299 (-)
CBA/J	ENSMUSG00210034410	protein coding gene	Chr14:33091493-33111591 (-)
DBA/2J	ENSMUSG00185013499	protein coding gene	Chr14:37318417-37338515 (-)
FVB/NJ	ENSMUSG00205045249	protein coding gene	Chr14:32926043-32946143 (-)
JF1/MsJ	ENSUMUG00000017926	protein coding gene	Chr14:44630423-44642253 (-)
LP/J	ENSMUSG00230016305	protein coding gene	Chr14:44640004-44656412 (-)
NOD/ShiLtJ	ENSMUSG00190021691	protein coding gene	Chr14:33127643-33139499 (-)
NZO/HlLtJ	ENSMUSG00225041668	protein coding gene	Chr14:38941999-38958414 (-)
PWK/PhJ	ENSLUMG00010032255	protein coding gene	Chr14:21178414-21190257 (-)
SPRET/EiJ	ENSMSPG00010002929	protein coding gene	Chr14:34934789-34946853 (-)
WSB/EiJ	ENSIUOG00005033289	protein coding gene	Chr14:32908863-32929017 (-)

Human Ortholog

DYDC2, DPY30 domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DYDC2, DPY30 domain containing 2
Links

HGNC:23468

NCBI Gene ID: 84332

UniProt: Q96IM9
Chr Location

10q23.1; chr10:80344730-80368074 (+) GRCh38

MGI Vertebrate Homology

Dydc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DYDC2
Gene Tree

Dydc2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
139 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Gene trapped

2
Targeted

2
Transgenic

1
Genomic Mutations

1 involving Dydc2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

1
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

605
Tissues

1
cDNA Data

7
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

14
UniProt

2
CCDS

CCDS26958.1

Ensembl

ENSMUSG00000021791 (Evidence)
NCBI Gene

71200

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021791	Ensembl Gene Model \| MGI Sequence Detail	20092	C57BL/6J	± kb
transcript	ENSMUST00000022316	Ensembl \| MGI Sequence Detail	818	Not Applicable
polypeptide	ENSMUSP00000022316	Ensembl \| MGI Sequence Detail	139	Not Applicable

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UniProt

2 Sequences
PDB

8WZB, 8X2U
InterPro Domains

IPR049630 DPY30 domain-containing protein-like, dimerization/docking domain

IPR007858 Dpy-30 motif

IPR037856 Sdc1/DPY30

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All nucleic 9

cDNA 7

Primer pair 2

Microarray probesets 3

Summaries

All 162

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 139
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:392230 Li T, et al., Local sympathetic signal enables the immune evasion of hepatic stellate cells. Neuron. 2026 Sep 16;

TSS for Dydc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128209	Chr14:40791150-40791169 (-)	5 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29