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Scara5 Gene Detail
Summary
  • Symbol
    Scara5
  • Name
    scavenger receptor class A, member 5
  • Synonyms
    4932433F15Rik, 4933425F03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918395
    NCBI Gene: 71145
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:65666403-65764826 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.35 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    867 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918395
protein coding gene Chr14:65666403-65764826 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021483
protein coding gene Chr14:60289312-60394745 (+)
A/J MGP_AJ_G0021442
protein coding gene Chr14:58887136-58986353 (+)
AKR/J MGP_AKRJ_G0021418
protein coding gene Chr14:60928594-61033687 (+)
BALB/cJ MGP_BALBcJ_G0021448
protein coding gene Chr14:58823521-58927479 (+)
C3H/HeJ MGP_C3HHeJ_G0021225
protein coding gene Chr14:60577648-60685220 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021887
protein coding gene Chr14:63067728-63178966 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019427
protein coding gene Chr14:56818987-56917110 (+)
CAST/EiJ MGP_CASTEiJ_G0020742
protein coding gene Chr14:57062982-57179678 (+)
CBA/J MGP_CBAJ_G0021192
protein coding gene Chr14:64979620-65091569 (+)
DBA/2J MGP_DBA2J_G0021315
protein coding gene Chr14:58534717-58635603 (+)
FVB/NJ MGP_FVBNJ_G0021294
protein coding gene Chr14:57935492-58041344 (+)
LP/J MGP_LPJ_G0021390
protein coding gene Chr14:61324418-61433623 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021323
protein coding gene Chr14:64073637-64177395 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021910
protein coding gene Chr14:60113429-60230495 (+)
PWK/PhJ MGP_PWKPhJ_G0020486
protein coding gene Chr14:55251584-55352553 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020319
protein coding gene Chr14:56083251-56194594 (+)
WSB/EiJ MGP_WSBEiJ_G0020795
protein coding gene Chr14:60418889-60526949 (+)



Homology
more
  • Human Ortholog
    SCARA5, scavenger receptor class A member 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SCARA5, scavenger receptor class A member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NET33, Tesr
  • Links
    NCBI Gene ID: 286133
    neXtProt AC: NX_Q6ZMJ2
    UniProt: Q6ZMJ2

  • Chr Location
    8p21.1; chr8:27869882-27992852 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12556
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SCARA5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous deletion of this gene results in decreased male fertility and lymphocytic infiltration of the stroma of various tissues, particularly in the lungs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71145 NCBI Gene Model | MGI Sequence Detail 98424 C57BL/6J ±  kb
    transcript NM_028903 RefSeq | MGI Sequence Detail 3809 C57BL/6  
    polypeptide Q8K299 UniProt | EBI | MGI Sequence Detail 491 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 48
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1921628, MGI:2145782
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 3
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:222495 Mendes-Jorge L, et al., L-ferritin binding to scara5: a new iron traffic pathway potentially implicated in retinopathy. PLoS One. 2014;9(9):e106974

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory