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Rfx4 Gene Detail
Summary
  • Symbol
    Rfx4
  • Name
    regulatory factor X, 4 (influences HLA class II expression)
  • Synonyms
    4933412G19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918387
    NCBI Gene: 71137
  • Gene Overview
    MyGene.info: RFX4
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:84756062-84906538 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 41.63 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    761 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918387
protein coding gene Chr10:84756048-84906538 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017594
protein coding gene Chr10:85635301-85796914 (+)
A/J MGP_AJ_G0017574
protein coding gene Chr10:82725745-82879744 (+)
AKR/J MGP_AKRJ_G0017533
protein coding gene Chr10:85028397-85187358 (+)
BALB/cJ MGP_BALBcJ_G0017537
protein coding gene Chr10:82976417-83127919 (+)
C3H/HeJ MGP_C3HHeJ_G0017359
protein coding gene Chr10:85115699-85272922 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017994
protein coding gene Chr10:88541217-88702942 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015678
protein coding gene Chr10:78545753-78690226 (+)
CAST/EiJ MGP_CASTEiJ_G0016926
protein coding gene Chr10:84965342-85128279 (+)
CBA/J MGP_CBAJ_G0017329
protein coding gene Chr10:92249388-92410326 (+)
DBA/2J MGP_DBA2J_G0017435
protein coding gene Chr10:81868245-82023549 (+)
FVB/NJ MGP_FVBNJ_G0017429
protein coding gene Chr10:81104754-81257517 (+)
LP/J MGP_LPJ_G0017507
protein coding gene Chr10:86270448-86429040 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017457
protein coding gene Chr10:93834689-94000748 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018031
protein coding gene Chr10:84949314-85105741 (+)
PWK/PhJ MGP_PWKPhJ_G0016707
protein coding gene Chr10:81731962-81885338 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016496
protein coding gene Chr10:83575024-83734277 (+)
WSB/EiJ MGP_WSBEiJ_G0016985
protein coding gene Chr10:84936694-85092068 (+)



Homology
more
  • Human Ortholog
    RFX4, regulatory factor X4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RFX4, regulatory factor X4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NYD-SP10
  • Links
    NCBI Gene ID: 5992
    neXtProt AC: NX_Q33E94
    UniProt: Q33E94

  • Chr Location
    12q23.3; chr12:106582907-106762804 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31119
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RFX4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Inactivating null allele or homozygous point mutation alleles exhibit missing dorsal midline structure of the cortex including the subcommissural organ and neonatal lethality. Heterozygous null mice have congenital hydrocephalus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020037 Ensembl Gene Model | MGI Sequence Detail 150477 C57BL/6J ±  kb
    transcript ENSMUST00000060397 Ensembl | MGI Sequence Detail 3534 Not Applicable  
    polypeptide ENSMUSP00000051107 Ensembl | MGI Sequence Detail 735 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 33
      Primer pair 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 15
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:255626 Xu P, et al., Conditional ablation of the RFX4 isoform 1 transcription factor: Allele dosage effects on brain phenotype. PLoS One. 2018;13(1):e0190561

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory