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Mterf4 Gene Detail
Summary
  • Symbol
    Mterf4
  • Name
    mitochondrial transcription termination factor 4
  • Synonyms
    1810059A23Rik, 4933412H03Rik, Mterfd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918355
    NCBI Gene: 69821
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:93301205-93305879 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 47.24 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918355
protein coding gene Chr1:93299211-93305915 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016338
protein coding gene Chr1:94917220-94923924 (-)
A/J MGP_AJ_G0016319
protein coding gene Chr1:91517149-91523851 (-)
AKR/J MGP_AKRJ_G0016280
protein coding gene Chr1:94217991-94224693 (-)
BALB/cJ MGP_BALBcJ_G0016275
protein coding gene Chr1:91698704-91705406 (-)
C3H/HeJ MGP_C3HHeJ_G0016104
protein coding gene Chr1:94472563-94479269 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016734
protein coding gene Chr1:98529693-98536397 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014452
protein coding gene Chr1:85766048-85772697 (-)
CAST/EiJ MGP_CASTEiJ_G0015687
protein coding gene Chr1:93801985-93808683 (-)
CBA/J MGP_CBAJ_G0016078
protein coding gene Chr1:101720383-101727075 (-)
DBA/2J MGP_DBA2J_G0016183
protein coding gene Chr1:90712461-90719163 (-)
FVB/NJ MGP_FVBNJ_G0016182
protein coding gene Chr1:89786966-89793668 (-)
LP/J MGP_LPJ_G0016254
protein coding gene Chr1:96096081-96102785 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016207
protein coding gene Chr1:104829413-104836115 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016773
protein coding gene Chr1:94234912-94241620 (-)
PWK/PhJ MGP_PWKPhJ_G0015472
protein coding gene Chr1:90150392-90157089 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015256
protein coding gene Chr1:93186103-93192797 (-)
WSB/EiJ MGP_WSBEiJ_G0015747
protein coding gene Chr1:94053870-94060570 (-)



Homology
more
  • Human Ortholog
    MTERF4, mitochondrial transcription termination factor 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MTERF4, mitochondrial transcription termination factor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MTERFD2
  • Links
    NCBI Gene ID: 130916
    neXtProt AC: NX_Q7Z6M4
    UniProt: Q7Z6M4

  • Chr Location
    2q37.3; chr2:241072168-241103367 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Mterf4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit complete embryonic lethality associated with decreased embryo size, lack of heart, and absence of optic discs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69821 NCBI Gene Model | MGI Sequence Detail 4675 C57BL/6J ±  kb
transcript NM_178051 RefSeq | MGI Sequence Detail 1330 C57BL/6  
polypeptide Q8BVN4 UniProt | EBI | MGI Sequence Detail 346 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000030235 mTERF domain-containing protein 2
  • InterPro Domains
    IPR038538 MTERF superfamily, mitochondrial/chloroplastic
    IPR003690 Transcription termination factor, mitochondrial/chloroplastic
Molecular
Reagents
less
  • All nucleic 43
    cDNA 43

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917071
References
more
  • Summaries
    All 34
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:254973 Kuhl I, et al., Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals. Elife. 2017 Nov 14;6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory