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Tssk4 Gene Detail
Summary
  • Symbol
    Tssk4
  • Name
    testis-specific serine kinase 4
  • Synonyms
    1700020B19Rik, 4933424F08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918349
    NCBI Gene: 71099
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:55650184-55652539 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2356 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TSSK4, testis specific serine kinase 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TSSK4, testis specific serine kinase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C14orf20, STK22E, TSK4, TSK-4, TSSK5
  • Links
    NCBI Gene ID: 283629
    neXtProt AC: NX_Q6SA08
    UniProt: Q6SA08

  • Chr Location
    14q12; chr14:24205524-24208362 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced male fertility, decreased sperm ferility and abnormal axoneme structure and sperm midpiece morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007591 Ensembl Gene Model | MGI Sequence Detail 2356 C57BL/6J ±  kb
transcript ENSMUST00000228395 Ensembl | MGI Sequence Detail 1273 Not Applicable  
polypeptide ENSMUSP00000154783 Ensembl | MGI Sequence Detail 338 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    18 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
Other
Accession IDs
less
MGI:1923651
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:263429 Fu G, et al., Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117. Biosci Biotechnol Biochem. 2016 Jun;80(6):1088-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory