Cdkl1 MGI Mouse Gene Detail - MGI:1918341 - cyclin dependent kinase like 1

Symbol

Cdkl1
Name

cyclin dependent kinase like 1
Synonyms

4933411O17Rik

Feature Type

protein coding gene
IDs

MGI:1918341
NCBI Gene: 71091
Alliance

genome feature page
Transcription Start Sites

13 TSS

Sequence Map

Chr12:69793622-69838041 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 28.94 cM
Mapping Data

1 experiment

SNPs within 2kb

1292 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918341	protein coding gene	Chr12:69791944-69838057 (-)
129S1/SvImJ	ENSMUSG00200031044	protein coding gene	Chr12:61713268-61757652 (-)
A/J	ENSMUSG00195012942	protein coding gene	Chr12:64403146-64447514 (-)
AKR/J	ENSMUSG00220014587	protein coding gene	Chr12:62203706-62248094 (-)
BALB/cJ	ENSMUSG00180032508	protein coding gene	Chr12:63402214-63446578 (-)
C3H/HeJ	ENSMUSG00175025720	protein coding gene	Chr12:66496616-66540993 (-)
C57BL/6NJ	ENSMUSG00215016802	protein coding gene	Chr12:62782548-62826971 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017811	protein coding gene	Chr12:64406653-64453384 (-)
CAST/EiJ	ENSTCUG00005034846	protein coding gene	Chr12:62741309-62789776 (-)
CBA/J	ENSMUSG00210029630	protein coding gene	Chr12:62966655-63011018 (-)
DBA/2J	ENSMUSG00185004317	protein coding gene	Chr12:64866044-64910401 (-)
FVB/NJ	ENSMUSG00205017263	protein coding gene	Chr12:62608074-62652494 (-)
JF1/MsJ	ENSUMUG00000017305	protein coding gene	Chr12:68828220-68876359 (-)
LP/J	ENSMUSG00230015703	protein coding gene	Chr12:71831420-71875782 (-)
NOD/ShiLtJ	ENSMUSG00190010716	protein coding gene	Chr12:62020158-62064528 (-)
NZO/HlLtJ	ENSMUSG00225037637	protein coding gene	Chr12:73915319-73959702 (-)
PWK/PhJ	ENSLUMG00010030735	protein coding gene	Chr12:62909226-62957522 (-)
SPRET/EiJ	ENSMSPG00010025136	protein coding gene	Chr12:64590075-64636683 (-)
WSB/EiJ	ENSIUOG00005011143	protein coding gene	Chr12:62653843-62698234 (-)

Human Ortholog

CDKL1, cyclin dependent kinase like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDKL1, cyclin dependent kinase like 1
Synonyms

KKIALRE, P42
Links

HGNC:1781

NCBI Gene ID: 8814

UniProt: Q00532
Chr Location

14q21.3; chr14:50326265-50416461 (-) GRCh38

MGI Vertebrate Homology

Cdkl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDKL1
Gene Tree

Cdkl1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

1
Targeted

3
Genomic Mutations

1 involving Cdkl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available

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All GO Annotations

16
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

606
Tissues

2
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdkl1

ZFIN cdkl1

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All Sequences

39
RefSeq

8
UniProt

2
CCDS

CCDS25955.1

Ensembl

ENSMUSG00000020990 (Evidence)
NCBI Gene

71091

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020990	Ensembl Gene Model \| MGI Sequence Detail	44420	C57BL/6J	± kb
transcript	ENSMUST00000021377	Ensembl \| MGI Sequence Detail	1689	Not Applicable
polypeptide	ENSMUSP00000021377	Ensembl \| MGI Sequence Detail	352	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005269 cyclin-dependent kinase-like 1

(term hierarchy)
EC

2.7.11.1, 2.7.11.22
InterPro Domains

IPR050108 Cyclin-dependent kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 12

cDNA 12

Microarray probesets 2

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:374603 Silvaroli JA, et al., Role of the CDKL1-SOX11 signaling axis in acute kidney injury. Am J Physiol Renal Physiol. 2024 Sep 1;327(3):F426-F434

TSS for Cdkl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116536	Chr12:69838127-69838138 (-)	-92 bp
Tssr116535	Chr12:69838099-69838112 (-)	-65 bp
Tssr116534	Chr12:69838085-69838097 (-)	-50 bp
Tssr116533	Chr12:69838068-69838069 (-)	-28 bp
Tssr116532	Chr12:69838003-69838067 (-)	6 bp
Tssr116531	Chr12:69837434-69837509 (-)	569 bp
Tssr116530	Chr12:69837379-69837405 (-)	649 bp
Tssr116529	Chr12:69837055-69837072 (-)	977 bp
Tssr116528	Chr12:69837048-69837050 (-)	992 bp
Tssr116527	Chr12:69837029-69837047 (-)	1,003 bp
Tssr116526	Chr12:69816507-69816516 (-)	21,529 bp
Tssr116525	Chr12:69816077-69816081 (-)	21,962 bp
Tssr116524	Chr12:69814061-69814066 (-)	23,977 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29