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Cdkl1
Gene Detail
Symbol

Name
ID
Cdkl1
cyclin-dependent kinase-like 1 (CDC2-related kinase)
MGI:1918341
Synonyms
4933411O17Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 12
28.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:69746848-69790707 bp, - strand
From Ensembl annotation of GRCm38

  43860 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55805  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdkl1

Human
homologs
Human Homolog CDKL1, cyclin-dependent kinase-like 1 (CDC2-related kinase)
NCBI Gene ID 8814
neXtProt AC  NX_Q00532
Human Synonyms  KKIALRE, P42
Human Chr (Location)  14q21.3; chr14:50329404-50416461 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cdkl1 interacts with 57 markers (Mir1a-1, Mir1a-2, Mir134, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process phosphorylation, protein phosphorylation
Component cytoplasm, extracellular vesicular exosome, ...
Function ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (9)    Tissues (2)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000020990 (Evidence)
Entrez Gene71091 (Evidence)
UniGene132325
DFCITC1585176
DoTSDT.60105124
NIA Mouse Gene IndexU034039
EC2.7.11.22
Consensus CDS ProjectCCDS25955.1
International Mouse Knockout Project StatusCdkl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020990 Ensembl Gene Model | MGI Sequence Detail 43860 C57BL/6J ±  kb
transcript ENSMUST00000021377 Ensembl | MGI Sequence Detail 1689 Not Applicable 
polypeptide ENSMUSP00000021377 Ensembl | MGI Sequence Detail 352 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(347 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005269 cyclin-dependent kinase-like 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory