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Zfp597 Gene Detail
Summary
  • Symbol
    Zfp597
  • Name
    zinc finger protein 597
  • Synonyms
    4933407K12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918313
    NCBI Gene: 71063
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:3861544-3884559 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 2.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918313
protein coding gene Chr16:3858321-3884561 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022452
protein coding gene Chr16:298551-327519 (-)
A/J MGP_AJ_G0022413
protein coding gene Chr16:180277-206377 (-)
AKR/J MGP_AKRJ_G0022390
protein coding gene Chr16:320583-348241 (-)
BALB/cJ MGP_BALBcJ_G0022418
protein coding gene Chr16:307165-333710 (-)
C3H/HeJ MGP_C3HHeJ_G0022185
protein coding gene Chr16:354154-379887 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022867
protein coding gene Chr16:338519-364675 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020389
protein coding gene Chr16:131310-158898 (-)
CAST/EiJ MGP_CASTEiJ_G0021712
protein coding gene Chr16:307723-337303 (-)
CBA/J MGP_CBAJ_G0022154
protein coding gene Chr16:400629-431727 (-)
DBA/2J MGP_DBA2J_G0022285
protein coding gene Chr16:288853-316274 (-)
FVB/NJ MGP_FVBNJ_G0022261
protein coding gene Chr16:260113-286192 (-)
LP/J MGP_LPJ_G0022354
protein coding gene Chr16:310926-337453 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022283
protein coding gene Chr16:293989-324818 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022879
protein coding gene Chr16:283731-310613 (-)
PWK/PhJ MGP_PWKPhJ_G0021452
protein coding gene Chr16:324242-351316 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021283
protein coding gene Chr16:387149-414306 (-)
WSB/EiJ MGP_WSBEiJ_G0021761
protein coding gene Chr16:314824-343813 (-)



Homology
more
  • Human Ortholog
    ZNF597, zinc finger protein 597
  • Vertebrate Orthologs
    6
  • Human Ortholog
    ZNF597, zinc finger protein 597
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HIT-4
  • Links
    NCBI Gene ID: 146434
    neXtProt AC: NX_Q96LX8
    UniProt: Q96LX8

  • Chr Location
    16p13.3; chr16:3432422-3443537 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality with a developmental arrest at the egg cylinder stage. Adult heterozygotes show ataxic or epileptic behaviors, spongiform pathology and neurodegeneration in the dorsal striatum and deep cortical layers.
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71063 NCBI Gene Model | MGI Sequence Detail 23016 C57BL/6J ±  kb
    transcript NM_001033159 RefSeq | MGI Sequence Detail 5630 C57BL/6  
    polypeptide NP_001028331 RefSeq | MGI Sequence Detail 419 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 40

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2146438, MGI:2146479
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory