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Prss55 Gene Detail
Summary
  • Symbol
    Prss55
  • Name
    protease, serine 55
  • Synonyms
    4933401F05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918287
    NCBI Gene: 71037
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:64075435-64085433 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 33.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918287
protein coding gene Chr14:64075435-64090162 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021469
protein coding gene Chr14:58640081-58654740 (-)
A/J MGP_AJ_G0021428
protein coding gene Chr14:57289624-57304518 (-)
AKR/J MGP_AKRJ_G0021404
protein coding gene Chr14:59316708-59331365 (-)
BALB/cJ MGP_BALBcJ_G0021434
protein coding gene Chr14:57247359-57262032 (-)
C3H/HeJ MGP_C3HHeJ_G0021211
protein coding gene Chr14:58943389-58958047 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021873
protein coding gene Chr14:61378776-61393422 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019413
protein coding gene Chr14:55225035-55239402 (-)
CAST/EiJ MGP_CASTEiJ_G0020728
protein coding gene Chr14:55400614-55416733 (-)
CBA/J MGP_CBAJ_G0021178
protein coding gene Chr14:63236793-63253460 (-)
DBA/2J MGP_DBA2J_G0021301
protein coding gene Chr14:56964891-56979553 (-)
FVB/NJ MGP_FVBNJ_G0021280
protein coding gene Chr14:56352797-56368117 (-)
LP/J MGP_LPJ_G0021376
protein coding gene Chr14:59673724-59688393 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021309
protein coding gene Chr14:62413289-62430438 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021896
protein coding gene Chr14:58479862-58494526 (-)
PWK/PhJ MGP_PWKPhJ_G0020472
protein coding gene Chr14:53640114-53655047 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020305
protein coding gene Chr14:54441857-54456479 (-)
WSB/EiJ MGP_WSBEiJ_G0020781
protein coding gene Chr14:58794760-58809414 (-)



Homology
more
  • Human Ortholog
    PRSS55, serine protease 55
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PRSS55, serine protease 55
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT153, TSP1, T-SP1, UNQ9391
  • Links
    NCBI Gene ID: 203074
    neXtProt AC: NX_Q6UWB4
    UniProt: Q6UWB4

  • Chr Location
    8p23.1; chr8:10525331-10554166 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show normal male fertility and testis morphology. Homozygotes for a different null allele show male infertility, decreased fertilization rate, impaired sperm migration into the oviduct, and defective sperm-egg recognition/binding but normal fertilization rate in vitro.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 71037 NCBI Gene Model | MGI Sequence Detail 9999 C57BL/6J ±  kb
transcript NM_001081063 RefSeq | MGI Sequence Detail 1041 C57BL/6  
polypeptide Q14BX2 UniProt | EBI | MGI Sequence Detail 321 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:278420 Shang X, et al., Serine protease PRSS55 is crucial for male mouse fertility via affecting sperm migration and sperm-egg binding. Cell Mol Life Sci. 2018 Dec;75(23):4371-4384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory