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Mex3b Gene Detail
Summary
  • Symbol
    Mex3b
  • Name
    mex3 RNA binding family member B
  • Synonyms
    4931439A04Rik, Rkhd3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918252
    NCBI Gene: 108797
  • Gene Overview
    MyGene.info: MEX3B
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:82867333-82871515 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 47.35 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918252
protein coding gene Chr7:82867333-82871576 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032446
protein coding gene Chr7:85005886-85011184 (+)
A/J MGP_AJ_G0032424
protein coding gene Chr7:82962010-82966054 (+)
AKR/J MGP_AKRJ_G0032360
protein coding gene Chr7:84845166-84849210 (+)
BALB/cJ MGP_BALBcJ_G0032436
protein coding gene Chr7:82626790-82630834 (+)
C3H/HeJ MGP_C3HHeJ_G0032150
protein coding gene Chr7:85410151-85414192 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032927
protein coding gene Chr7:88300788-88305018 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029937
protein coding gene Chr7:85387102-85391323 (+)
CAST/EiJ MGP_CASTEiJ_G0031477
protein coding gene Chr7:76378344-76382577 (+)
CBA/J MGP_CBAJ_G0032115
protein coding gene Chr7:91234259-91238300 (+)
DBA/2J MGP_DBA2J_G0032270
protein coding gene Chr7:81471229-81475270 (+)
FVB/NJ MGP_FVBNJ_G0032224
protein coding gene Chr7:81432414-81436535 (+)
LP/J MGP_LPJ_G0032351
protein coding gene Chr7:86217152-86221421 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032261
protein coding gene Chr7:91278087-91282954 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032947
protein coding gene Chr7:84250725-84254956 (+)
PWK/PhJ MGP_PWKPhJ_G0031197
protein coding gene Chr7:74696248-74700472 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031039
protein coding gene Chr7:71241048-71245288 (+)
WSB/EiJ MGP_WSBEiJ_G0031594
protein coding gene Chr7:84615700-84619932 (+)



Homology
more
  • Human Ortholog
    MEX3B, mex-3 RNA binding family member B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MEX3B, mex-3 RNA binding family member B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MEX-3B, RKHD3, RNF195
  • Links
    NCBI Gene ID: 84206
    neXtProt AC: NX_Q6ZN04
    UniProt: Q6ZN04

  • Chr Location
    15q25.2; chr15:82041778-82046143 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to partial neonatal lethality, decreased body weight and subfertility. Males show seminiferous tubule obstruction, oligozoospermia, abnormalities in Sertoli cell barrier morphology and function, and impaired Sertoli cell and macrophage phagocytosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057706 Ensembl Gene Model | MGI Sequence Detail 4183 C57BL/6J ±  kb
transcript ENSMUST00000082237 Ensembl | MGI Sequence Detail 3355 Not Applicable  
polypeptide ENSMUSP00000082168 Ensembl | MGI Sequence Detail 576 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 4
Other
Accession IDs
less
MGI:1934873
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:238930 Yamazumi Y, et al., The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation. Cell Rep. 2016 Aug 30;16(9):2456-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory