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Agbl4 Gene Detail
Summary
  • Symbol
    Agbl4
  • Name
    ATP/GTP binding protein-like 4
  • Synonyms
    4930578N11Rik, 4931433A01Rik, Ccp6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918244
    NCBI Gene: 78933
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:110397661-111664324 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 51.43 cM, cytoband C7
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8704 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918244
protein coding gene Chr4:110397639-111664324 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028577
protein coding gene Chr4:111195394-112519871 (+)
A/J MGP_AJ_G0028540
protein coding gene Chr4:107197461-108435013 (+)
AKR/J MGP_AKRJ_G0028487
protein coding gene Chr4:109884546-111137014 (+)
BALB/cJ MGP_BALBcJ_G0028559
protein coding gene Chr4:107403428-108660945 (+)
C3H/HeJ MGP_C3HHeJ_G0028273
protein coding gene Chr4:110622149-111869875 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028999
protein coding gene Chr4:115204913-116572567 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026290
protein coding gene Chr4:102475419-103607893 (+)
CAST/EiJ MGP_CASTEiJ_G0027709
protein coding gene Chr4:108487340-109736674 (+)
CBA/J MGP_CBAJ_G0028242
protein coding gene Chr4:118974666-120358593 (+)
DBA/2J MGP_DBA2J_G0028390
protein coding gene Chr4:106824989-108095501 (+)
FVB/NJ MGP_FVBNJ_G0028358
protein coding gene Chr4:105679047-106917965 (+)
LP/J MGP_LPJ_G0028491
protein coding gene Chr4:111477876-112793811 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028384
protein coding gene Chr4:124212573-125748764 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029035
protein coding gene Chr4:110114997-111385261 (+)
PWK/PhJ MGP_PWKPhJ_G0027435
protein coding gene Chr4:105110524-106339699 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027259
protein coding gene Chr4:107522630-108742388 (+)
WSB/EiJ MGP_WSBEiJ_G0027790
protein coding gene Chr4:110299131-111612844 (+)



Homology
more
  • Human Ortholog
    AGBL4, ATP/GTP binding protein like 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AGBL4, ATP/GTP binding protein like 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CCP6
  • Links
    NCBI Gene ID: 84871
    neXtProt AC: NX_Q5VU57
    UniProt: Q5VU57

  • Chr Location
    1p33; chr1:48520157-50024011 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 84880
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AGBL4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal platelet morphology and physiology, impaired megakaryopoiesis, increased spleen weight and increased susceptibility to HSV or VACV infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061298 Ensembl Gene Model | MGI Sequence Detail 1266664 C57BL/6J ±  kb
    transcript ENSMUST00000097920 Ensembl | MGI Sequence Detail 1798 Not Applicable  
    polypeptide ENSMUSP00000095533 Ensembl | MGI Sequence Detail 540 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1926183
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:259707 Ye B, et al., Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory