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Prss54 Gene Detail
Summary
  • Symbol
    Prss54
  • Name
    serine protease 54
  • Synonyms
    4931432M23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918243
    NCBI Gene: 70993
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:96285694-96302965 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 47.12 cM, cytoband C5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    284 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918243
 protein coding gene Chr8:96285694-96302968 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033989
 protein coding gene Chr8:97045134-97063096 (-)
A/J MGP_AJ_G0033972
 protein coding gene Chr8:93240984-93257012 (-)
AKR/J MGP_AKRJ_G0033898
 protein coding gene Chr8:95776305-95792729 (-)
BALB/cJ MGP_BALBcJ_G0033964
 protein coding gene Chr8:93328226-93345864 (-)
C3H/HeJ MGP_C3HHeJ_G0033674
 protein coding gene Chr8:96514131-96531466 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034485
 protein coding gene Chr8:100596987-100613038 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031426
 protein coding gene Chr8:87044424-87060345 (-)
CAST/EiJ MGP_CASTEiJ_G0033006
 protein coding gene Chr8:96101756-96118224 (-)
CBA/J MGP_CBAJ_G0033650
 protein coding gene Chr8:103885369-103901572 (-)
DBA/2J MGP_DBA2J_G0033804
 protein coding gene Chr8:92731852-92748449 (-)
FVB/NJ MGP_FVBNJ_G0033751
 protein coding gene Chr8:91686253-91702596 (-)
LP/J MGP_LPJ_G0033896
 protein coding gene Chr8:97179986-97196191 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033793
 protein coding gene Chr8:106114593-106144730 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034503
 protein coding gene Chr8:95969295-95986888 (-)
PWK/PhJ MGP_PWKPhJ_G0032708
 protein coding gene Chr8:92093835-92112647 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032545
 protein coding gene Chr8:94811551-94828758 (-)
WSB/EiJ MGP_WSBEiJ_G0033118
 protein coding gene Chr8:96477773-96493986 (-)



Homology
more
  • Human Ortholog
    PRSS54, serine protease 54
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS54, serine protease 54
  • Synonyms
    CT67, KLKBL4
  • Links
    NCBI Gene ID: 221191
    neXtProt AC: NX_Q6PEW0
    UniProt: Q6PEW0

  • Chr Location
    16q21; chr16:58279997-58295047 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for one null allele exhibit normal fertility. Mice homozygous for a different null allele exhibit reduced male fertility, abnormal acrosome, and defective sperm-zona penetration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70993 NCBI Gene Model | MGI Sequence Detail 17272 C57BL/6J ±  kb
    transcript NM_001310539 RefSeq | MGI Sequence Detail 1590 C57BL/6  
    polypeptide Q7M756 UniProt | EBI | MGI Sequence Detail 383 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 2
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 30
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:332475 Shen C, et al., Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in mice. Biol Reprod. 2022 Oct 11;107(4):1139-1154
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory