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Mterf1a Gene Detail
Summary
  • Symbol
    Mterf1a
  • Name
    mitochondrial transcription termination factor 1a
  • Synonyms
    4931431L11Rik, 9230106K09Rik, Mterf, Mterf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918240
    NCBI Gene: 545725
Location & Maps
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  • Genetic Map
    Chromosome 5, 2.26 cM
  • Mapping Data
    1 experiment
Homology
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  • Human Ortholog
    MTERF1, mitochondrial transcription termination factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MTERF1, mitochondrial transcription termination factor 1
    Orthology source: HomoloGene
  • Synonyms
    MTERF
  • Links
    NCBI Gene ID: 7978
    neXtProt AC: NX_Q99551

  • Chr Location
    7q21.2; chr7:91872876-91880720 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from multigenic genotypes
    6 phenotype references
  • All Mutations and Alleles
    7
  • Gene trapped
    2
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a knock-out allele of both Mterf1a and Mterf1b exhibit impaired transcription initiation at light-strand promoters resulting in a decrease of de novo transcription and reduced 7S RNA.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028565 VEGA Gene Model | MGI Sequence Detail 3353 C57BL/6J ±  kb
transcript OTTMUST00000070795 VEGA | MGI Sequence Detail 1376 Not Applicable  
polypeptide OTTMUSP00000036133 VEGA | MGI Sequence Detail 379 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    42 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR003690 Transcription termination factor, mitochondrial/chloroplastic
Molecular
Reagents
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  • All nucleic 9
    cDNA 9

    Microarray probesets 1
Other
Accession IDs
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MGI:1925325
References
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  • Summaries
    All 27
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:198969 Terzioglu M, et al., MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation. Cell Metab. 2013 Apr 2;17(4):618-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory