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Trim45 Gene Detail
Summary
  • Symbol
    Trim45
  • Name
    tripartite motif-containing 45
  • Synonyms
    4921530N01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918187
    NCBI Gene: 229644
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:100829518-100844236 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 43.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918187
protein coding gene Chr3:100828516-100844241 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027670
protein coding gene Chr3:102058650-102074630 (+)
A/J MGP_AJ_G0027629
protein coding gene Chr3:98843933-98858575 (+)
AKR/J MGP_AKRJ_G0027595
protein coding gene Chr3:101266435-101281167 (+)
BALB/cJ MGP_BALBcJ_G0027642
protein coding gene Chr3:98604261-98618921 (+)
C3H/HeJ MGP_C3HHeJ_G0027371
protein coding gene Chr3:101562427-101577173 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028085
protein coding gene Chr3:105803713-105820170 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025426
protein coding gene Chr3:95039446-95054114 (+)
CAST/EiJ MGP_CASTEiJ_G0026827
protein coding gene Chr3:100659240-100673816 (+)
CBA/J MGP_CBAJ_G0027346
protein coding gene Chr3:109449577-109464362 (+)
DBA/2J MGP_DBA2J_G0027489
protein coding gene Chr3:98082727-98097502 (+)
FVB/NJ MGP_FVBNJ_G0027457
protein coding gene Chr3:96015854-96031077 (+)
LP/J MGP_LPJ_G0027596
protein coding gene Chr3:103422050-103437702 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027487
protein coding gene Chr3:115674827-115689557 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028140
protein coding gene Chr3:100755035-100769711 (+)
PWK/PhJ MGP_PWKPhJ_G0026554
protein coding gene Chr3:97838066-97852933 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026376
protein coding gene Chr3:98852958-98866781 (+)
WSB/EiJ MGP_WSBEiJ_G0026907
protein coding gene Chr3:101318245-101334437 (+)



Homology
more
  • Human Ortholog
    TRIM45, tripartite motif containing 45
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM45, tripartite motif containing 45
  • Synonyms
    RNF99
  • Links
    NCBI Gene ID: 80263
    neXtProt AC: NX_Q9H8W5
    UniProt: Q9H8W5

  • Chr Location
    1p13.1; chr1:117111060-117123927 (-)  GRCh38

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033233 Ensembl Gene Model | MGI Sequence Detail 14719 C57BL/6J ±  kb
    transcript ENSMUST00000134993 Ensembl | MGI Sequence Detail 2274 Not Applicable  
    polypeptide ENSMUSP00000115669 Ensembl | MGI Sequence Detail 757 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 2
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345487 Zhang J, et al., E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2. Cell Death Differ. 2023 Apr;30(4):966-978

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory