About   Help   FAQ
Setd2
Gene Detail
Symbol

Name
ID
Setd2
SET domain containing 2
MGI:1918177
Synonyms
4921524K10Rik, KMT3A
Feature Type
protein coding gene
Genetic Map
Chromosome 9
60.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:110532597-110618633 bp, + strand
From Ensembl annotation of GRCm38

  86037 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Setd2

Human
homologs
Human Homolog   SETD2, SET domain containing 2
NCBI Gene ID 29072
neXtProt AC  NX_Q9BYW2
Human Synonyms  HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, p231HBP, SET2
Human Chr (Location)  3p21.31; chr3:47016408-47163977 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(22) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit impaired embryonic vascular remodeling in the embryo proper, yolk sac, and placenta that leads to death around E10.5.
 
Interactions
Setd2 interacts with 498 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process angiogenesis, cell migration involved in vasculogenesis, ...
Component chromosome, nucleus
Function histone-lysine N-methyltransferase activity, methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(161)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(162) cDNA(161) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000044791 (Evidence)
Entrez Gene235626 (Evidence)
UniGene288949
DFCITC1597545, TC1697785, TC1698441, TC1658415, TC1604143, TC1651850
DoTSDT.101369912, DT.101344932, DT.492832, DT.483825, DT.110610678, DT.91368384
NIA Mouse Gene IndexU279495, U011069
EC2.1.1.43
Consensus CDS ProjectCCDS40781.2
International Mouse Knockout Project StatusSetd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044791 Ensembl Gene Model | MGI Sequence Detail 86037 C57BL/6J ±  kb
transcript ENSMUST00000153838 Ensembl | MGI Sequence Detail 8350 Not Applicable 
polypeptide ENSMUSP00000116313 Ensembl | MGI Sequence Detail 2537 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(18) UniProt(2)
Polymorphisms
SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006560 AWS
InterPro IPR003616 Post-SET domain
InterPro IPR001214 SET domain
InterPro IPR013257 SRI, Set2 Rpb1 interacting
InterPro IPR001202 WW domain
Protein Ontology PR:000014721 histone-lysine N-methyltransferase SETD2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203796 Zhang K, et al., CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev Biol. 2013 Nov 1;383(1):15-27
All references(40)
Other
accession IDs
MGI:2446266

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/07/2015
MGI 5.21
The Jackson Laboratory