Setd2
Gene Detail

Symbol Name ID

Setd2 SET domain containing 2 MGI:1918177

Synonyms

4921524K10Rik, KMT3A

Feature Type

protein coding gene

Genetic Map

Chromosome 9

60.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:110532597-110618633 bp, + strand From VEGA annotation of GRCm38   86037 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Setd2

Human homologs

Human Homolog		SETD2, SET domain containing 2
NCBI Gene ID		29072
neXtProt AC		NX_Q9BYW2
Human Synonyms		HBP231, HIF-1, HIP-1, HYPB, KMT3A, p231HBP, SET2
Human Chr (Location)		3p21.31; chr3:47057898-47205467 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(23) : Targeted(1) Gene trapped(22)
 

Mice homozygous for a knock-out allele exhibit impaired embryonic vascular remodeling in the embryo proper, yolk sac, and placenta that leads to death around E10.5.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	angiogenesis, cell migration involved in vasculogenesis, ...
Component	nucleus
Function	methyltransferase activity, transferase activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000033479 (Evidence)
Ensembl Gene Model	ENSMUSG00000044791 (Evidence)
Entrez Gene	235626 (Evidence)
DFCI	TC1597545, TC1604143, TC1651850, TC1658415, TC1697785, TC1698441
DoTS	DT.483825, DT.101344932, DT.101369912, DT.110610678, DT.492832, DT.91368384
NIA Mouse Gene Index	U011069, U279495
Consensus CDS Project	CCDS40781.2
International Mouse Knockout Project Status	Setd2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033479	VEGA Gene Model | MGI Sequence Detail	86037	C57BL/6J
transcript	OTTMUST00000084141	VEGA | MGI Sequence Detail	8350	Not Applicable
polypeptide	OTTMUSP00000045304	VEGA | MGI Sequence Detail	2537	Not Applicable

All sequences(76) RefSeq(2) UniProt(10)

Polymorphisms

SNPs(113 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006560	AWS
InterPro	IPR003616	Post-SET domain
InterPro	IPR001214	SET domain
InterPro	IPR013257	SRI, Set2 Rpb1 interacting
InterPro	IPR001202	WW domain
Protein Ontology	PR:000014721	histone-lysine N-methyltransferase SETD2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)

Other accession IDs

MGI:2446266