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Setd2
Gene Detail
Symbol

Name
ID
Setd2
SET domain containing 2
MGI:1918177
Synonyms
4921524K10Rik, KMT3A
Feature Type
protein coding gene
Genetic Map
Chromosome 9
60.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:110532597-110618633 bp, + strand
From Ensembl annotation of GRCm38

  86037 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SETD2
Gene Tree: Setd2

Human
homologs
SETD2, SET domain containing 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 29072
neXtProt AC: NX_Q9BYW2

Human Synonyms: HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, p231HBP, SET2

Human Chr (Location): 3p21.31; chr3:47016408-47163977 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(22) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit impaired embryonic vascular remodeling in the embryo proper, yolk sac, and placenta that leads to death around E10.5.
 
Interactions
Setd2 interacts with 498 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(161)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase setd2 ; ZFIN setd2    NEW 
Molecular
reagents
All nucleic(162) cDNA(161) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000044791 (Evidence)
Entrez Gene 235626 (Evidence)
UniGene 288949
DFCI TC1597545, TC1604143, TC1651850, TC1658415, TC1697785, TC1698441
DoTS DT.101344932, DT.101369912, DT.110610678, DT.483825, DT.492832, DT.91368384
NIA Mouse Gene Index U011069, U279495
EC 2.1.1.43
Consensus CDS Project CCDS40781.2
International Mouse Phenotyping Consortium Status Setd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044791 Ensembl Gene Model | MGI Sequence Detail 86037 C57BL/6J ±  kb
transcript ENSMUST00000153838 Ensembl | MGI Sequence Detail 8350 Not Applicable 
polypeptide ENSMUSP00000116313 Ensembl | MGI Sequence Detail 2537 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(18) UniProt(7)
Polymorphisms
SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006560 AWS
InterPro IPR003616 Post-SET domain
InterPro IPR001214 SET domain
InterPro IPR013257 SRI, Set2 Rpb1 interacting
InterPro IPR001202 WW domain
Protein Ontology PR:000014721 histone-lysine N-methyltransferase SETD2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203796 Zhang K, et al., CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev Biol. 2013 Nov 1;383(1):15-27
All references(38)
Other
accession IDs
MGI:2446266

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory