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Cnbd2 Gene Detail
Summary
  • Symbol
    Cnbd2
  • Name
    cyclic nucleotide binding domain containing 2
  • Synonyms
    4921517L17Rik, 5430421B09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918123
    NCBI Gene: 70873
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:156312402-156375638 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 77.39 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    592 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918123
protein coding gene Chr2:156312299-156375638 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026763
protein coding gene Chr2:161190787-161254914 (+)
A/J MGP_AJ_G0026729
protein coding gene Chr2:154793203-154851339 (+)
AKR/J MGP_AKRJ_G0026700
protein coding gene Chr2:159280883-159346828 (+)
BALB/cJ MGP_BALBcJ_G0026738
protein coding gene Chr2:155078193-155134021 (+)
C3H/HeJ MGP_C3HHeJ_G0026481
protein coding gene Chr2:159632561-159690092 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027187
protein coding gene Chr2:165915230-165978880 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024557
protein coding gene Chr2:148261487-148319802 (+)
CAST/EiJ MGP_CASTEiJ_G0025942
protein coding gene Chr2:159965337-160025149 (+)
CBA/J MGP_CBAJ_G0026458
protein coding gene Chr2:171948195-172013840 (+)
DBA/2J MGP_DBA2J_G0026595
protein coding gene Chr2:153960059-154019489 (+)
FVB/NJ MGP_FVBNJ_G0026562
protein coding gene Chr2:152331120-152392046 (+)
LP/J MGP_LPJ_G0026700
protein coding gene Chr2:161316163-161379355 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026583
protein coding gene Chr2:175885521-175948242 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027243
protein coding gene Chr2:159153758-159214050 (+)
PWK/PhJ MGP_PWKPhJ_G0025676
protein coding gene Chr2:153460651-153517916 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025479
protein coding gene Chr2:158096347-158156579 (+)
WSB/EiJ MGP_WSBEiJ_G0026012
protein coding gene Chr2:160043038-160104877 (+)



Homology
more
  • Human Ortholog
    CNBD2, cyclic nucleotide binding domain containing 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CNBD2, cyclic nucleotide binding domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf152, CNMPD1
  • Links
    NCBI Gene ID: 140894
    neXtProt AC: NX_Q96M20
    UniProt: Q96M20

  • Chr Location
    20q11.23; chr20:35954561-36030700 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced male fertility associated with impaired spermiogenesis and development of flagellum bending.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 70873 NCBI Gene Model | MGI Sequence Detail 63237 C57BL/6J ±  kb
transcript NM_027585 RefSeq | MGI Sequence Detail 2106 C57BL/6  
polypeptide Q9D5U8 UniProt | EBI | MGI Sequence Detail 673 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR018488 Cyclic nucleotide-binding, conserved site
    IPR000595 Cyclic nucleotide-binding domain
    IPR038897 Cyclic nucleotide-binding domain-containing protein 2
    IPR018490 Cyclic nucleotide-binding-like
    IPR014710 RmlC-like jelly roll fold
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 4
Other
Accession IDs
less
MGI:1918593
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:207897 Krahling AM, et al., CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending. PLoS Genet. 2013 Dec;9(12):e1003960

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory