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Vwa3b Gene Detail
Summary
  • Symbol
    Vwa3b
  • Name
    von Willebrand factor A domain containing 3B
  • Synonyms
    4921511C04Rik, A230074B11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918103
    NCBI Gene: 70853
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:37029158-37187608 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 15.46 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1390 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918103
 protein coding gene Chr1:37026596-37187613 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015934
 protein coding gene Chr1:35608235-35789427 (+)
A/J MGP_AJ_G0015918
 protein coding gene Chr1:34631603-34797832 (+)
AKR/J MGP_AKRJ_G0015873
 protein coding gene Chr1:35130265-35298308 (+)
BALB/cJ MGP_BALBcJ_G0015872
 protein coding gene Chr1:34318620-34485663 (+)
C3H/HeJ MGP_C3HHeJ_G0015705
 protein coding gene Chr1:35330021-35501644 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016325
 protein coding gene Chr1:37194551-37379016 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014047
 protein coding gene Chr1:31672383-31838747 (+)
CAST/EiJ MGP_CASTEiJ_G0015286
 protein coding gene Chr1:35205235-35382610 (+)
CBA/J MGP_CBAJ_G0015677
 protein coding gene Chr1:38183542-38380442 (+)
DBA/2J MGP_DBA2J_G0015778
 protein coding gene Chr1:33967624-34133937 (+)
FVB/NJ MGP_FVBNJ_G0015780
 protein coding gene Chr1:33498041-33666072 (+)
LP/J MGP_LPJ_G0015848
 protein coding gene Chr1:35961932-36140202 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015800
 protein coding gene Chr1:40378246-40559948 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016372
 protein coding gene Chr1:35183564-35353977 (+)
PWK/PhJ MGP_PWKPhJ_G0015069
 protein coding gene Chr1:33726758-33895110 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014851
 protein coding gene Chr1:35126004-35288265 (+)
WSB/EiJ MGP_WSBEiJ_G0015348
 protein coding gene Chr1:35133245-35307483 (+)



Homology
more
  • Human Ortholog
    VWA3B, von Willebrand factor A domain containing 3B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VWA3B, von Willebrand factor A domain containing 3B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SCAR22
  • Links
    NCBI Gene ID: 200403
    neXtProt AC: NX_Q502W6
    UniProt: Q502W6

  • Chr Location
    2q11.2; chr2:98087132-98330675 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human VWA3B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Male mice homozygous for a null allele exhibit normal fecundity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • cDNA Data
    19
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70853 NCBI Gene Model | MGI Sequence Detail 158451 C57BL/6J ±  kb
transcript NM_001370828 RefSeq | MGI Sequence Detail 4552 C57BL/6  
polypeptide NP_001357757 RefSeq | MGI Sequence Detail 1226 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    10 Sequences
  • InterPro Domains
    IPR032770 Domain of unknown function DUF4537
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 3
Other
Accession IDs
less
MGI:2443831, MGI:2685401
References
more
  • Summaries
    All 29
    Gene Ontology 1
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:279039 Lu Y, et al., CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in micedagger. Biol Reprod. 2019 Aug 1;101(2):501-511
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/26/2020
MGI 6.15 		The Jackson Laboratory