Vwa3b Gene Detail

Summary

• Symbol
  Vwa3b
• Name
  von Willebrand factor A domain containing 3B
• Synonyms
  4921511C04Rik, A230074B11Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1918103
  NCBI Gene: 70853
• Alliance
  gene page
• Transcription Start Sites
  8 TSS

Location &
Maps

• Sequence Map
  Chr1:37028812-37187608 bp, + strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 15.46 cM, cytoband B
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  1390 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918103	protein coding gene	Chr1:37026596-37187613 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015934	protein coding gene	Chr1:35608235-35789427 (+)
A/J	MGP_AJ_G0015918	protein coding gene	Chr1:34631603-34797832 (+)
AKR/J	MGP_AKRJ_G0015873	protein coding gene	Chr1:35130265-35298308 (+)
BALB/cJ	MGP_BALBcJ_G0015872	protein coding gene	Chr1:34318620-34485663 (+)
C3H/HeJ	MGP_C3HHeJ_G0015705	protein coding gene	Chr1:35330021-35501644 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016325	protein coding gene	Chr1:37194551-37379016 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014047	protein coding gene	Chr1:31672383-31838747 (+)
CAST/EiJ	MGP_CASTEiJ_G0015286	protein coding gene	Chr1:35205235-35382610 (+)
CBA/J	MGP_CBAJ_G0015677	protein coding gene	Chr1:38183542-38380442 (+)
DBA/2J	MGP_DBA2J_G0015778	protein coding gene	Chr1:33967624-34133937 (+)
FVB/NJ	MGP_FVBNJ_G0015780	protein coding gene	Chr1:33498041-33666072 (+)
LP/J	MGP_LPJ_G0015848	protein coding gene	Chr1:35961932-36140202 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015800	protein coding gene	Chr1:40378246-40559948 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016372	protein coding gene	Chr1:35183564-35353977 (+)
PWK/PhJ	MGP_PWKPhJ_G0015069	protein coding gene	Chr1:33726758-33895110 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014851	protein coding gene	Chr1:35126004-35288265 (+)
WSB/EiJ	MGP_WSBEiJ_G0015348	protein coding gene	Chr1:35133245-35307483 (+)

Homology

• Human Ortholog
  VWA3B, von Willebrand factor A domain containing 3B

• Vertebrate Orthologs
  9

• Human Ortholog
  VWA3B, von Willebrand factor A domain containing 3B
  Orthology source: HomoloGene, HGNC
• Synonyms
  SCAR22
• Links
  HGNC:28385

  NCBI Gene ID: 200403

  neXtProt AC: NX_Q502W6

  UniProt: Q502W6

  
  
• Chr Location
  2q11.2; chr2:98087132-98330675 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 27053
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: VWA3B
• Gene Tree
  Vwa3b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotype references
  

• All Mutations and Alleles
  115
• Chemically induced (other)
  1
• Gene trapped
  111
• Targeted
  3
• Genomic Mutations
  1 involving Vwa3b
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  3 strains or lines available

Gene Ontology
(GO)
Classifications

• External Resources
  FuncBase

Expression

• cDNA Data
  19

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase vwa3b

Interactions

• Vwa3b interacts with 220 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

Sequences &
Gene Models

• All Sequences
  69
• RefSeq
  17
• UniProt
  8
• UniGene
  148848

• Ensembl
  ENSMUSG00000050122 (Evidence)
• NCBI Gene
  70853

Representative Sequences			Length	Strain/Species
genomic	70853	NCBI Gene Model | MGI Sequence Detail	158797	C57BL/6J
transcript	AK038906	GenBank | EMBL | DDBJ | MGI Sequence Detail	1771	C57BL/6J
polypeptide	J9JI28	UniProt | EBI | MGI Sequence Detail	736	Not Applicable

Protein
Information

• UniProt
  8 Sequences
• InterPro Domains
  IPR032770 Domain of unknown function DUF4537
  IPR036465 von Willebrand factor A-like domain superfamily
  IPR002035 von Willebrand factor, type A

Molecular
Reagents

• All nucleic 19

  cDNA 19

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:2443831, MGI:2685401

References

• Summaries
  All 27

  Phenotypes 9
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Vwa3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6295	Chr1:37029307-37029339 (+)	511 bp
Tssr6296	Chr1:37029347-37029357 (+)	540 bp
Tssr6297	Chr1:37100609-37100616 (+)	71,801 bp
Tssr6298	Chr1:37100660-37100672 (+)	71,854 bp
Tssr45	Chr1:37153822-37153825 (+)	125,012 bp
Tssr6299	Chr1:37153840-37153857 (+)	125,037 bp
Tssr6300	Chr1:37153858-37153870 (+)	125,052 bp
Tssr6301	Chr1:37153874-37153896 (+)	125,073 bp