Vwa3b MGI Mouse Gene Detail - MGI:1918103 - von Willebrand factor A domain containing 3B

Symbol

Vwa3b
Name

von Willebrand factor A domain containing 3B
Synonyms

4921511C04Rik, A230074B11Rik

Feature Type

protein coding gene
IDs

MGI:1918103
NCBI Gene: 70853
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:37068372-37226689 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 15.46 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

1381 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918103	protein coding gene	Chr1:37065677-37226694 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015934	protein coding gene	Chr1:35608235-35789427 (+)
A/J	MGP_AJ_G0015918	protein coding gene	Chr1:34631603-34797832 (+)
AKR/J	MGP_AKRJ_G0015873	protein coding gene	Chr1:35130265-35298308 (+)
BALB/cJ	MGP_BALBcJ_G0015872	protein coding gene	Chr1:34318620-34485663 (+)
C3H/HeJ	MGP_C3HHeJ_G0015705	protein coding gene	Chr1:35330021-35501644 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016325	protein coding gene	Chr1:37194551-37379016 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014047	protein coding gene	Chr1:31672383-31838747 (+)
CAST/EiJ	MGP_CASTEiJ_G0015286	protein coding gene	Chr1:35205235-35382610 (+)
CBA/J	MGP_CBAJ_G0015677	protein coding gene	Chr1:38183542-38380442 (+)
DBA/2J	MGP_DBA2J_G0015778	protein coding gene	Chr1:33967624-34133937 (+)
FVB/NJ	MGP_FVBNJ_G0015780	protein coding gene	Chr1:33498041-33666072 (+)
LP/J	MGP_LPJ_G0015848	protein coding gene	Chr1:35961932-36140202 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015800	protein coding gene	Chr1:40378246-40559948 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016372	protein coding gene	Chr1:35183564-35353977 (+)
PWK/PhJ	MGP_PWKPhJ_G0015069	protein coding gene	Chr1:33726758-33895110 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014851	protein coding gene	Chr1:35126004-35288265 (+)
WSB/EiJ	MGP_WSBEiJ_G0015348	protein coding gene	Chr1:35133245-35307483 (+)

Human Ortholog

VWA3B, von Willebrand factor A domain containing 3B

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VWA3B, von Willebrand factor A domain containing 3B
Synonyms

SCAR22
Links

HGNC:28385

NCBI Gene ID: 200403

neXtProt AC: NX_Q502W6

UniProt: Q502W6
Chr Location

2q11.2; chr2:98087132-98330675 (+) GRCh38.p7

Alliance of Genome Resources

Vwa3b stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: VWA3B
Gene Tree

Vwa3b

Diseases

1 with human VWA3B associations

				Human Disease	Mouse Models
				autosomal recessive spinocerebellar ataxia 22 IDs autosomal recessive spinocerebellar ataxia 22 DOID:0111614 OMIM:616948

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

All Mutations and Alleles

63
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

58
Targeted

3
Genomic Mutations

1 involving Vwa3b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

Male mice homozygous for a null allele exhibit normal fecundity.

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All GO Annotations

2
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

672
cDNA Data

19

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vwa3b

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Vwa3b interacts with 220 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

77
RefSeq

19
UniProt

10

Ensembl

ENSMUSG00000050122 (Evidence)
NCBI Gene

70853

			Length	Strain/Species	Flank
genomic	70853	NCBI Gene Model \| MGI Sequence Detail	158318	C57BL/6J	± kb
transcript	NM_001370828	RefSeq \| MGI Sequence Detail	4552	C57BL/6
polypeptide	NP_001357757	RefSeq \| MGI Sequence Detail	1226	C57BL/6

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UniProt

10 Sequences
InterPro Domains

IPR032770 Domain of unknown function DUF4537

IPR002999 Tudor domain

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A

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All nucleic 19

cDNA 19

Microarray probesets 3

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MGI:2443831, MGI:2685401

Summaries

All 29

Gene Ontology 1

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:279039 Lu Y, et al., CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice. Biol Reprod. 2019 Aug 1;101(2):501-511

TSS for Vwa3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6295	Chr1:37068388-37068420 (+)	32 bp
Tssr6296	Chr1:37068428-37068438 (+)	61 bp
Tssr44	Chr1:37128739-37128741 (+)	60,368 bp
Tssr6297	Chr1:37139690-37139697 (+)	71,322 bp
Tssr6298	Chr1:37139741-37139753 (+)	71,375 bp
Tssr45	Chr1:37192903-37192906 (+)	124,533 bp
Tssr6299	Chr1:37192921-37192938 (+)	124,558 bp
Tssr6300	Chr1:37192939-37192951 (+)	124,573 bp
Tssr6301	Chr1:37192955-37192977 (+)	124,594 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/21/2021 MGI 6.17