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Ttc6 Gene Detail
Summary
  • Symbol
    Ttc6
  • Name
    tetratricopeptide repeat domain 6
  • Synonyms
    4921506M07Rik, AU024163, EG639426, Gm9813, LOC217602
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684915
    NCBI Gene: 70846
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:57610899-57784714 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 24.70 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    732 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684915
 protein coding gene Chr12:57593490-57784714 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019762
 protein coding gene Chr12:56740559-56940765 (+)
A/J MGP_AJ_G0019721
 protein coding gene Chr12:54670773-54849847 (+)
AKR/J MGP_AKRJ_G0019696
 protein coding gene Chr12:56404927-56577438 (+)
BALB/cJ MGP_BALBcJ_G0019701
 protein coding gene Chr12:55041598-55214175 (+)
C3H/HeJ MGP_C3HHeJ_G0019506
 protein coding gene Chr12:56491324-56677079 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020153
 protein coding gene Chr12:58433215-58608830 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017773
 protein coding gene Chr12:53124993-53294315 (+)
CAST/EiJ MGP_CASTEiJ_G0019058
 protein coding gene Chr12:51418957-51591751 (+)
CBA/J MGP_CBAJ_G0019475
 protein coding gene Chr12:60516356-60712319 (+)
DBA/2J MGP_DBA2J_G0019591
 protein coding gene Chr12:54587176-54751974 (+)
FVB/NJ MGP_FVBNJ_G0019579
 protein coding gene Chr12:53870306-54042696 (+)
LP/J MGP_LPJ_G0019663
 protein coding gene Chr12:56720649-56899029 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019617
 protein coding gene Chr12:62058574-62284031 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020187
 protein coding gene Chr12:55855392-56036961 (+)
PWK/PhJ MGP_PWKPhJ_G0018825
 protein coding gene Chr12:48981513-49159879 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018618
 protein coding gene Chr12:50289370-50465425 (+)
WSB/EiJ MGP_WSBEiJ_G0019109
 protein coding gene Chr12:56394485-56579467 (+)



Homology
more
  • Human Ortholog
    TTC6, tetratricopeptide repeat domain 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTC6, tetratricopeptide repeat domain 6
  • Synonyms
    C14orf25, NCRNA00291
  • Links
    NCBI Gene ID: 319089
    UniProt: Q86TZ1

  • Chr Location
    14q21.1; chr14:37595629-38041442 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced male fertility, impaired binding of sperm to zona pellucida, decreased sperm progressive motility, and hairpin sperm flagellum.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    14
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046782 Ensembl Gene Model | MGI Sequence Detail 173816 C57BL/6J ±  kb
    transcript ENSMUST00000172939 Ensembl | MGI Sequence Detail 5782 Not Applicable  
    polypeptide ENSMUSP00000134273 Ensembl | MGI Sequence Detail 1857 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR006597 Sel1-like repeat
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR001440 Tetratricopeptide repeat 1
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1918096, MGI:3034924, MGI:3645573
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 2
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:341550 Wang Z, et al., TTC6-Mediated Stabilization of the Flagellum Annulus Ensures the Rapid and Directed Motion of Sperm. Cells. 2023 Aug 18;12(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory