About   Help   FAQ
Prss22
Gene Detail
 Symbol
Name
ID
Prss22
protease, serine 22
MGI:1918085
Synonyms 4733401N09Rik, BSSP-4, SP001LA
Feature Type protein coding gene
Genetic Map
Chromosome 17
12.18 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:23993535-23998100 bp, - strand
From Ensembl annotation of GRCm38

  4566 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23344  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Prss22

Human
homologs
Human Homolog PRSS22, protease, serine, 22
NCBI Gene ID 64063
neXtProt AC  NX_Q9GZN4
Human Synonyms  BSSP-4, hBSSP-4
Human Chr (Location)  16p13.3; chr16:2852727-2858630 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Prss22 interacts with 66 markers (Mir1a-1, Mir1a-2, Mir32, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process proteolysis
Component cellular_component
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (20)    Tissues (20)    Images (1)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RT-PCR 20
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000045027 (Evidence)
Entrez Gene70835 (Evidence)
UniGene157351
DFCITC1591668, TC1736296
DoTSDT.55253606
NIA Mouse Gene IndexU065892
EC3.4.21.-
Consensus CDS ProjectCCDS37482.1
International Mouse Knockout Project StatusPrss22
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045027 Ensembl Gene Model | MGI Sequence Detail 4566 C57BL/6J ±  kb
transcript ENSMUST00000041649 Ensembl | MGI Sequence Detail 1323 Not Applicable 
polypeptide ENSMUSP00000039808 Ensembl | MGI Sequence Detail 307 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000013322 brain-specific serine protease 4
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory