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Hmgxb4 Gene Detail
Summary
  • Symbol
    Hmgxb4
  • Name
    HMG box domain containing 4
  • Synonyms
    4733401K04Rik, Hmgb2l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918073
    NCBI Gene: 70823
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:75720305-75758606 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 35.57 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    726 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918073
 protein coding gene Chr8:75719984-75758606 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033793
 protein coding gene Chr8:75435994-75481481 (+)
A/J MGP_AJ_G0033775
 protein coding gene Chr8:72477482-72517128 (+)
AKR/J MGP_AKRJ_G0033702
 protein coding gene Chr8:74683524-74725870 (+)
BALB/cJ MGP_BALBcJ_G0033769
 protein coding gene Chr8:72571267-72613742 (+)
C3H/HeJ MGP_C3HHeJ_G0033478
 protein coding gene Chr8:75238345-75283808 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034289
 protein coding gene Chr8:78366441-78407734 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031230
 protein coding gene Chr8:66746318-66787244 (+)
CAST/EiJ MGP_CASTEiJ_G0032807
 protein coding gene Chr8:74522143-74560044 (+)
CBA/J MGP_CBAJ_G0033457
 protein coding gene Chr8:81119745-81162328 (+)
DBA/2J MGP_DBA2J_G0033611
 protein coding gene Chr8:72159306-72204651 (+)
FVB/NJ MGP_FVBNJ_G0033556
 protein coding gene Chr8:71243013-71281649 (+)
LP/J MGP_LPJ_G0033700
 protein coding gene Chr8:75567876-75608703 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033599
 protein coding gene Chr8:83682072-83724039 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034306
 protein coding gene Chr8:74652406-74691614 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0032351
 protein coding gene Chr8:73535215-73582175 (+)
WSB/EiJ MGP_WSBEiJ_G0032922
 protein coding gene Chr8:74958678-74997837 (+)



Homology
more
  • Human Ortholog
    HMGXB4, HMG-box containing 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGXB4, HMG-box containing 4
  • Synonyms
    HMG2L1, HMGBCG, P53N, THC211630
  • Links
    NCBI Gene ID: 10042
    UniProt: Q9UGU5

  • Chr Location
    22q12.3; chr22:35241536-35295807 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are protected against LPS-induced acute lung injury and against septic shock-induced lethality.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    78
  • cDNA Data
    101
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70823 NCBI Gene Model | MGI Sequence Detail 38302 C57BL/6J ±  kb
    transcript NM_001316753 RefSeq | MGI Sequence Detail 3991 C57BL/6  
    polypeptide NP_821136 RefSeq | MGI Sequence Detail 594 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR025228 Domain of unknown function DUF4171
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR042477 HMG domain-containing protein 4
      IPR048016 HMG domain-containing protein 4, HMG-box
    • GlyGen
      Q80Y32 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 105
      Genomic 1
      cDNA 101
      Primer pair 3
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142500
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 7
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347593 Wang L, et al., A novel mouse model carrying a gene trap insertion into the Hmgxb4 gene locus to examine Hmgxb4 expression in vivo. Physiol Rep. 2024 Apr;12(8):e16014
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/09/2026
    MGI 6.24     		The Jackson Laboratory