About   Help   FAQ
Pgrmc2 Gene Detail
Summary
  • Symbol
    Pgrmc2
  • Name
    progesterone receptor membrane component 2
  • Synonyms
    4631434O19Rik, 5730409G06Rik, DG6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918054
    NCBI Gene: 70804
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:41066326-41083046 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 19.66 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918054
protein coding gene Chr3:41066326-41083046 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027185
protein coding gene Chr3:39070445-39087158 (-)
A/J MGP_AJ_G0027145
protein coding gene Chr3:38113959-38131372 (-)
AKR/J MGP_AKRJ_G0027114
protein coding gene Chr3:38835479-38852317 (-)
BALB/cJ MGP_BALBcJ_G0027157
protein coding gene Chr3:37886949-37903877 (-)
C3H/HeJ MGP_C3HHeJ_G0026900
protein coding gene Chr3:38959868-38977239 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027603
protein coding gene Chr3:40685802-40707940 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024963
protein coding gene Chr3:35621837-35638401 (-)
CAST/EiJ MGP_CASTEiJ_G0026353
protein coding gene Chr3:38828304-38846150 (-)
CBA/J MGP_CBAJ_G0026877
protein coding gene Chr3:41837420-41856109 (-)
DBA/2J MGP_DBA2J_G0027011
protein coding gene Chr3:37581305-37598061 (-)
FVB/NJ MGP_FVBNJ_G0026979
protein coding gene Chr3:36951541-36968218 (-)
LP/J MGP_LPJ_G0027123
protein coding gene Chr3:39812017-39830362 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026997
protein coding gene Chr3:44304497-44323511 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027662
protein coding gene Chr3:38705150-38721824 (-)
PWK/PhJ MGP_PWKPhJ_G0026085
protein coding gene Chr3:37257562-37274440 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025898
protein coding gene Chr3:38100127-38116495 (-)
WSB/EiJ MGP_WSBEiJ_G0026427
protein coding gene Chr3:38711162-38729342 (-)



Homology
more
  • Human Ortholog
    PGRMC2, progesterone receptor membrane component 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PGRMC2, progesterone receptor membrane component 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DG6, PMBP
  • Links
    NCBI Gene ID: 10424
    neXtProt AC: NX_O15173
    UniProt: O15173

  • Chr Location
    4q28.2; chr4:128269237-128288829 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38169
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PGRMC2
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in the uterus exhibit early female reproductive senescence, decreased uterine NK cell number, increased endometrial gland number and uterine cysts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70804 NCBI Gene Model | MGI Sequence Detail 16721 C57BL/6J ±  kb
    transcript NM_027558 RefSeq | MGI Sequence Detail 3022 C57BL/6  
    polypeptide Q80UU9 UniProt | EBI | MGI Sequence Detail 217 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000012623 membrane-associated progesterone receptor component 2
    • InterPro Domains
      IPR001199 Cytochrome b5-like heme/steroid binding domain
      IPR036400 Cytochrome b5-like heme/steroid binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 96

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1917743
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:247103 Clark NC, et al., Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence. Endocrinology. 2017 Mar 01;158(3):640-651

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory