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Ubr5 Gene Detail
Summary
  • Symbol
    Ubr5
  • Name
    ubiquitin protein ligase E3 component n-recognin 5
  • Synonyms
    4432411E13Rik, Edd, Edd1, mKIAA0896
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918040
    NCBI Gene: 70790
  • Gene Overview
    MyGene.info: UBR5
Location & Maps
more
  • Sequence Map
    Chr15:37967328-38078853 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      111526 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 15.10 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    UBR5, ubiquitin protein ligase E3 component n-recognin 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    UBR5, ubiquitin protein ligase E3 component n-recognin 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DD5, EDD, EDD1, HYD
  • Links
    NCBI Gene ID: 51366
    neXtProt AC: NX_O95071

  • Chr Location
    8q22; chr8:102252273-102412689 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9295
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: UBR5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    153
  • Chemically induced (other)
    2
  • Gene trapped
    148
  • Targeted
    3
  • Genomic Mutations
    2 involving Ubr5
  • Incidental Mutations
Homozygous null mice display embryonic lethality during organogenesis, impaired growth of the allantois, failure or impairment of chorioallantoic fusion, impaired angiogenesis in the yolk sac and allantois, decreased cell proliferation, and increased apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037487 Ensembl Gene Model | MGI Sequence Detail 111526 C57BL/6J ±  kb
transcript ENSMUST00000110336 Ensembl | MGI Sequence Detail 9790 Not Applicable  
polypeptide ENSMUSP00000105965 Ensembl | MGI Sequence Detail 2798 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    409 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000017016 E3 ubiquitin-protein ligase UBR5
  • EC
  • InterPro Domains
    IPR024725 E3 ubiquitin ligase EDD, ubiquitin-associated domain
    IPR000569 HECT domain
    IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
    IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
    IPR003126 Zinc finger, UBR-type
Molecular
Reagents
less
  • All nucleic 454
    cDNA 454

    Microarray probesets 2
Other
Accession IDs
less
MGI:2146233, MGI:2146275
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:213926 Zhang T, et al., UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12091-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory