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Ubr5
Gene Detail
Symbol

Name
ID
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
MGI:1918040
Synonyms
4432411E13Rik, Edd, Edd1, mKIAA0896
Feature Type
protein coding gene
Genetic Map
Chromosome 15
15.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:37967328-38078853 bp, - strand
From Ensembl annotation of GRCm38

  111526 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9295  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UBR5
Gene Tree: Ubr5

Human
homologs
UBR5, ubiquitin protein ligase E3 component n-recognin 5
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51366
neXtProt AC: NX_O95071

Human Synonyms: DD5, EDD, EDD1, HYD

Human Chr (Location): 8q22; chr8:102252273-102412689 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(151) : Gene trapped(148) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display embryonic lethality during organogenesis, impaired growth of the allantois, failure or impairment of chorioallantoic fusion, impaired angiogenesis in the yolk sac and allantois, decreased cell proliferation, and increased apoptosis.
 
Interactions
Ubr5 interacts with 350 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (134)    Tissues (21)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 134
cDNA source data(454)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ubr5    NEW 
Molecular
reagents
All nucleic(454) cDNA(454)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000037487 (Evidence)
Entrez Gene 70790 (Evidence)
UniGene 476840
DFCI TC1664148, TC1605732, TC1588239, TC1626988, TC1616786, TC1573380
DoTS DT.101394920, DT.101394923, DT.101739157, DT.495135, DT.91588835, DT.99844589, DT.97379568
NIA Mouse Gene Index U036111
EC 6.3.2.-
Consensus CDS Project CCDS49595.1
International Mouse Phenotyping Consortium Status Ubr5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037487 Ensembl Gene Model | MGI Sequence Detail 111526 C57BL/6J ±  kb
transcript ENSMUST00000110336 Ensembl | MGI Sequence Detail 9790 Not Applicable 
polypeptide ENSMUSP00000105965 Ensembl | MGI Sequence Detail 2798 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(18) UniProt(4)
Polymorphisms
SNPs within 2kb(411 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024725 E3 ubiquitin ligase EDD, ubiquitin-associated domain
InterPro IPR000569 HECT
InterPro IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
InterPro IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
InterPro IPR003126 Zinc finger, N-recognin
InterPro IPR013993 Zinc finger, N-recognin, metazoa
Protein Ontology PR:000017016 E3 ubiquitin-protein ligase UBR5
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:174373 Su H, et al., Mammalian hyperplastic discs Homolog EDD Regulates miRNA-Mediated Gene Silencing. Mol Cell. 2011 Jul 8;43(1):97-109
All references(41)
Other
accession IDs
MGI:2146233, MGI:2146275

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory