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Ubr5
Gene Detail
 Symbol
Name
ID
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
MGI:1918040
Synonyms 4432411E13Rik, Edd, Edd1, mKIAA0896
Feature Type protein coding gene
Genetic Map
Chromosome 15
15.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:37967328-38078853 bp, - strand
From NCBI annotation of GRCm38

  111526 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9295  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ubr5

Human
homologs
Human Homolog UBR5, ubiquitin protein ligase E3 component n-recognin 5
NCBI Gene ID 51366
neXtProt AC  NX_O95071
Human Synonyms  DD5, EDD, EDD1, HYD
Human Chr (Location)  8q22; chr8:102252273-102412719 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(151) : Gene trapped(148) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality during organogenesis, impaired growth of the allantois, failure or impairment of chorioallantoic fusion, impaired angiogenesis in the yolk sac and allantois, decreased cell proliferation, and increased apoptosis.
 
Interactions
Ubr5 interacts with 351 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component cytoplasm, membrane, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (134)    Tissues (21)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 134
cDNA source data(454)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(454) cDNA(454)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000037487 (Evidence)
Entrez Gene70790 (Evidence)
UniGene476840
DFCITC1573380, TC1588239, TC1605732, TC1616786, TC1626988, TC1664148
DoTSDT.101394920, DT.101394923, DT.101739157, DT.495135, DT.91588835, DT.97379568, DT.99844589
NIA Mouse Gene IndexU036111
EC6.3.2.-
Consensus CDS ProjectCCDS49595.1
International Mouse Knockout Project StatusUbr5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 70790 NCBI Gene Model | MGI Sequence Detail 111526 C57BL/6J ±  kb
transcript NM_001081359 RefSeq | MGI Sequence Detail 9791 C57BL/6 
polypeptide Q80TP3 UniProt | EBI | MGI Sequence Detail 2792 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(18) UniProt(4)
Polymorphisms SNPs within 2kb(411 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024725 E3 ubiquitin ligase EDD, ubiquitin-associated domain
InterPro IPR000569 HECT
InterPro IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
InterPro IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
InterPro IPR003126 Zinc finger, N-recognin
InterPro IPR013993 Zinc finger, N-recognin, metazoa
Protein Ontology PR:000017016 E3 ubiquitin-protein ligase UBR5
Graphical View of Protein Domain Structure
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:174373 Su H, et al., Mammalian hyperplastic discs Homolog EDD Regulates miRNA-Mediated Gene Silencing. Mol Cell. 2011 Jul 8;43(1):97-109
All references(43)
Other
accession IDs
MGI:2146233, MGI:2146275

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory