About   Help   FAQ
Ubr5 Gene Detail
Summary
  • Symbol
    Ubr5
  • Name
    ubiquitin protein ligase E3 component n-recognin 5
  • Synonyms
    4432411E13Rik, Edd, Edd1, mKIAA0896
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918040
    NCBI Gene: 70790
  • Gene Overview
    MyGene.info: UBR5
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:37967328-38078854 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 15.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    409 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918040
protein coding gene Chr15:37967328-38078854 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021805
protein coding gene Chr15:36453450-36569006 (-)
A/J MGP_AJ_G0021765
protein coding gene Chr15:35048650-35159988 (-)
AKR/J MGP_AKRJ_G0021745
protein coding gene Chr15:36076864-36193907 (-)
BALB/cJ MGP_BALBcJ_G0021772
protein coding gene Chr15:35093010-35204163 (-)
C3H/HeJ MGP_C3HHeJ_G0021546
protein coding gene Chr15:36027572-36140644 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022211
protein coding gene Chr15:37872437-37987538 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019748
protein coding gene Chr15:32826885-32942388 (-)
CAST/EiJ MGP_CASTEiJ_G0021063
protein coding gene Chr15:36423828-36541814 (-)
CBA/J MGP_CBAJ_G0021515
protein coding gene Chr15:39078470-39194910 (-)
DBA/2J MGP_DBA2J_G0021639
protein coding gene Chr15:34890741-35002323 (-)
FVB/NJ MGP_FVBNJ_G0021617
protein coding gene Chr15:34291508-34404097 (-)
LP/J MGP_LPJ_G0021709
protein coding gene Chr15:36312416-36430442 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021641
protein coding gene Chr15:42107603-42224579 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022234
protein coding gene Chr15:36224715-36337002 (-)
PWK/PhJ MGP_PWKPhJ_G0020807
protein coding gene Chr15:34923501-35037819 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020645
protein coding gene Chr15:35905868-36017626 (-)
WSB/EiJ MGP_WSBEiJ_G0021118
protein coding gene Chr15:36168018-36286211 (-)



Homology
more
  • Human Ortholog
    UBR5, ubiquitin protein ligase E3 component n-recognin 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    UBR5, ubiquitin protein ligase E3 component n-recognin 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DD5, EDD, EDD1, HYD
  • Links
    NCBI Gene ID: 51366
    neXtProt AC: NX_O95071
    UniProt: O95071

  • Chr Location
    8q22.3; chr8:102252273-102412719 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9295
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UBR5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis, impaired growth of the allantois, failure or impairment of chorioallantoic fusion, impaired angiogenesis in the yolk sac and allantois, decreased cell proliferation, and increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70790 NCBI Gene Model | MGI Sequence Detail 111527 C57BL/6J ±  kb
    transcript NM_001081359 RefSeq | MGI Sequence Detail 9791 C57BL/6  
    polypeptide Q80TP3 UniProt | EBI | MGI Sequence Detail 2792 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • EC
    • InterPro Domains
      IPR024725 E3 ubiquitin ligase EDD, ubiquitin-associated domain
      IPR000569 HECT domain
      IPR035983 HECT, E3 ligase catalytic domain
      IPR036053 PABC (PABP) domain
      IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
      IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
      IPR003126 Zinc finger, UBR-type
    Molecular
    Reagents
    less
    • All nucleic 455
      cDNA 455

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2146233, MGI:2146275
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:236026 Kinsella E, et al., Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development. PLoS One. 2016;11(6):e0157079

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory