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Kynu Gene Detail
Summary
  • Symbol
    Kynu
  • Name
    kynureninase (L-kynurenine hydrolase)
  • Synonyms
    4432411A05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918039
    NCBI Gene: 70789
  • Gene Overview
    MyGene.info: KYNU
Location & Maps
more
  • Sequence Map
    Chr2:43555329-43682715 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      127387 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KYNU, kynureninase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KYNU, kynureninase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KYNUU
  • Links
    NCBI Gene ID: 8942
    neXtProt AC: NX_Q16719

  • Chr Location
    2q22.2; chr2:142748928-143042316 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KYNU associations

Human Disease Mouse Models
       Hydroxykynureninuria   OMIM: 236800
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012317 VEGA Gene Model | MGI Sequence Detail 127387 C57BL/6J ±  kb
transcript OTTMUST00000029322 VEGA | MGI Sequence Detail 2733 Not Applicable  
polypeptide OTTMUSP00000013230 VEGA | MGI Sequence Detail 465 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1578 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000009598 kynureninase
  • EC
  • InterPro Domains
    IPR000192 Aminotransferase class V domain
    IPR010111 Kynureninase
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 4
References
more
  • Summaries
    All 23
    Gene Ontology 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory