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Kynu Gene Detail
Summary
  • Symbol
    Kynu
  • Name
    kynureninase
  • Synonyms
    4432411A05Rik, L-kynurenine hydrolase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918039
    NCBI Gene: 70789
  • Gene Overview
    MyGene.info: KYNU
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:43555329-43682715 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 25.64 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1578 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918039
protein coding gene Chr2:43555257-43683048 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025715
protein coding gene Chr2:42539709-42674927 (+)
A/J MGP_AJ_G0025691
protein coding gene Chr2:40828953-40957341 (+)
AKR/J MGP_AKRJ_G0025661
protein coding gene Chr2:42088788-42222120 (+)
BALB/cJ MGP_BALBcJ_G0025686
protein coding gene Chr2:40891498-41016664 (+)
C3H/HeJ MGP_C3HHeJ_G0025447
protein coding gene Chr2:42030491-42166654 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026132
protein coding gene Chr2:43820550-43965003 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023538
protein coding gene Chr2:39165345-39293479 (+)
CAST/EiJ MGP_CASTEiJ_G0024912
protein coding gene Chr2:42029244-42176525 (+)
CBA/J MGP_CBAJ_G0025427
protein coding gene Chr2:45525639-45678506 (+)
DBA/2J MGP_DBA2J_G0025558
protein coding gene Chr2:40499807-40626570 (+)
FVB/NJ MGP_FVBNJ_G0025520
protein coding gene Chr2:40331133-40455730 (+)
LP/J MGP_LPJ_G0025646
protein coding gene Chr2:42366127-42500991 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025551
protein coding gene Chr2:45794687-45941700 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026190
protein coding gene Chr2:41997908-42132407 (+)
PWK/PhJ MGP_PWKPhJ_G0024653
protein coding gene Chr2:40422509-40549696 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024458
protein coding gene Chr2:42082597-42221900 (+)
WSB/EiJ MGP_WSBEiJ_G0024979
protein coding gene Chr2:42163516-42299100 (+)



Homology
more
  • Human Ortholog
    KYNU, kynureninase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KYNU, kynureninase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KYNUU, VCRL2
  • Links
    NCBI Gene ID: 8942
    neXtProt AC: NX_Q16719
    UniProt: Q16719

  • Chr Location
    2q22.2; chr2:142877626-143042316 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026866 Ensembl Gene Model | MGI Sequence Detail 127387 C57BL/6J ±  kb
transcript ENSMUST00000028223 Ensembl | MGI Sequence Detail 2733 Not Applicable  
polypeptide ENSMUSP00000028223 Ensembl | MGI Sequence Detail 465 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 4
References
more
  • Summaries
    All 27
    Gene Ontology 7
    Phenotypes 1
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory