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Kynu
Gene Detail
Symbol

Name
ID
Kynu
kynureninase (L-kynurenine hydrolase)
MGI:1918039
Synonyms
4432411A05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
25.64 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:43555329-43682715 bp, + strand
From VEGA annotation of GRCm38

  127387 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2925  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: KYNU
Gene Tree: Kynu

Human
homologs
Human Homolog KYNU, kynureninase
NCBI Gene ID 8942
neXtProt AC  NX_Q16719
Human Chr (Location)  2q22.2; chr2:142877626-143042316 (+)  GRCh38
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Kynu interacts with 250 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process anthranilate metabolic process, metabolic process, ...
Component cytoplasm, cytosol, ...
Function catalytic activity, hydrolase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000012317 (Evidence)
Ensembl Gene ModelENSMUSG00000026866 (Evidence)
Entrez Gene70789 (Evidence)
UniGene105278
DFCITC1585539
DoTSDT.101214315, DT.101263271, DT.102540396, DT.91346084, DT.99842903
NIA Mouse Gene IndexU001716
EC3.7.1.3
Consensus CDS ProjectCCDS16018.1
International Mouse Knockout Project StatusKynu
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012317 VEGA Gene Model | MGI Sequence Detail 127387 C57BL/6J ±  kb
transcript OTTMUST00000029322 VEGA | MGI Sequence Detail 2733 Not Applicable 
polypeptide OTTMUSP00000013230 VEGA | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(12) UniProt(6)
Polymorphisms
SNPs within 2kb(1587 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000192 Aminotransferase, class V/Cysteine desulfurase
InterPro IPR010111 Kynureninase
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology PR:000009598 kynureninase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory