Kynu
Gene Detail

Symbol Name ID

Kynu kynureninase (L-kynurenine hydrolase) MGI:1918039

Synonyms

4432411A05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

25.64 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:43555329-43682715 bp, + strand From VEGA annotation of GRCm38   127387 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2925  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: KYNU
Gene Tree: Kynu

Human homologs

Human Homolog		KYNU, kynureninase
NCBI Gene ID		8942
neXtProt AC		NX_Q16719
Human Chr (Location)		2q22.2; chr2:143635195-143799885 (+)  GRCh37.p10

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	anthranilate metabolic process, metabolic process, ...
Component	cytoplasm, cytosol, ...
Function	catalytic activity, hydrolase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(21)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000012317 (Evidence)
Ensembl Gene Model	ENSMUSG00000026866 (Evidence)
Entrez Gene	70789 (Evidence)
UniGene	105278
DFCI	TC1585539
DoTS	DT.101214315, DT.102540396, DT.91346084, DT.99842903
NIA Mouse Gene Index	U001716
EC	3.7.1.3
Consensus CDS Project	CCDS16018.1
International Mouse Knockout Project Status	Kynu

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012317	VEGA Gene Model | MGI Sequence Detail	127387	C57BL/6J
transcript	OTTMUST00000029322	VEGA | MGI Sequence Detail	2733	Not Applicable
polypeptide	OTTMUSP00000013230	VEGA | MGI Sequence Detail	465	Not Applicable

All sequences(43) RefSeq(2) UniProt(6)

Polymorphisms

SNPs within 2kb(1587 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000192	Aminotransferase, class V/Cysteine desulfurase
InterPro	IPR010111	Kynureninase
InterPro	IPR015424	Pyridoxal phosphate-dependent transferase
InterPro	IPR015421	Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro	IPR015422	Pyridoxal phosphate-dependent transferase, major region, subdomain 2
Protein Ontology	PR:000009598	kynureninase

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(28)