Prpf3
Gene Detail

Symbol Name ID

Prpf3 PRP3 pre-mRNA processing factor 3 homolog (yeast) MGI:1918017

Synonyms

3632413F13Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 3

41.25 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:95830124-95855885 bp, - strand From VEGA annotation of GRCm38   25762 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3447  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Prpf3

Human homologs

Human Homolog		PRPF3, PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)
NCBI Gene ID		9129
neXtProt AC		NX_O43395
Human Synonyms		HPRP3, HPRP3P, PRP3, Prp3p, RP18
Human Chr (Location)		1q21.1; chr1:150293928-150325704 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PRPF3

Alleles and phenotypes

All alleles(30) : Targeted(3) Gene trapped(27)
 

Mice homozygous for a null mutation display embryonic lethality.

 
Human Diseases Modeled Using Mouse Prpf3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	mRNA processing, RNA splicing
Component	Cajal body, cytoplasm, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (22)    Tissues (22)    Images (5)
Theiler Stages: 21, 28

Assay Type	Results
RNA in situ	20
RT-PCR	2

cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(67) cDNA(66) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000030680 (Evidence)
Ensembl Gene Model	ENSMUSG00000015748 (Evidence)
Entrez Gene	70767 (Evidence)
UniGene	279872
DFCI	TC1578125, TC1615373, TC1623331
DoTS	DT.101376790, DT.489817, DT.91317270, DT.94155436
NIA Mouse Gene Index	U024371
Consensus CDS Project	CCDS17621.1
International Mouse Knockout Project Status	Prpf3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030680	VEGA Gene Model | MGI Sequence Detail	25762	C57BL/6J
transcript	OTTMUST00000075939	VEGA | MGI Sequence Detail	2933	Not Applicable
polypeptide	OTTMUSP00000039899	VEGA | MGI Sequence Detail	683	Not Applicable

All sequences(54) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(112 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010541	Domain of unknown function DUF1115
InterPro	IPR013881	Pre-mRNA-splicing factor 3
InterPro	IPR002483	Splicing factor PWI
Protein Ontology	PR:000013278	U4/U6 small nuclear ribonucleoprotein Prp3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:175792 Jelcick AS, et al., Genetic variations strongly influence phenotypic outcome in the mouse retina. PLoS One. 2011;6(7):e21858
All references(37)