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Prpf3
Gene Detail
Symbol

Name
ID
Prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
MGI:1918017
Synonyms
3632413F13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
41.25 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:95830124-95855885 bp, - strand
From VEGA annotation of GRCm38

  25762 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3447  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRPF3
Gene Tree: Prpf3

Human
homologs
PRPF3, pre-mRNA processing factor 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9129
neXtProt AC: NX_O43395

Human Synonyms: HPRP3, HPRP3P, PRP3, Prp3p, RP18, SNRNP90

Human Chr (Location): 1q21.1; chr1:150321479-150353228 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PRPF3

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(27) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display embryonic lethality.
 
Human Diseases Modeled in Mice Using Prpf3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Prpf3 interacts with 160 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process mRNA processing, mRNA splicing, via spliceosome, ...
Component Cajal body, cytoplasm, ...
Function identical protein binding, poly(A) RNA binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (22)    Tissues (22)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
RT-PCR 2
cDNA source data(65)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prpf3    NEW 
Molecular
reagents
All nucleic(66) cDNA(65) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000030680 (Evidence)
Ensembl Gene Model ENSMUSG00000015748 (Evidence)
Entrez Gene 70767 (Evidence)
UniGene 279872
DFCI TC1578125, TC1615373, TC1623331
DoTS DT.101376790, DT.489817, DT.91317270, DT.94155436
NIA Mouse Gene Index U024371
Consensus CDS Project CCDS17621.1
International Mouse Phenotyping Consortium Status Prpf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030680 VEGA Gene Model | MGI Sequence Detail 25762 C57BL/6J ±  kb
transcript OTTMUST00000075939 VEGA | MGI Sequence Detail 2933 Not Applicable 
polypeptide OTTMUSP00000039899 VEGA | MGI Sequence Detail 683 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010541 Domain of unknown function DUF1115
InterPro IPR013881 Pre-mRNA-splicing factor 3
InterPro IPR002483 PWI domain
InterPro IPR027104 U4/U6 small nuclear ribonucleoprotein Prp3
Protein Ontology PR:000013278 U4/U6 small nuclear ribonucleoprotein Prp3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:216059 Farkas MH, et al., Mutations in pre-mRNA processing factors 3, 8, and 31 cause dysfunction of the retinal pigment epithelium. Am J Pathol. 2014 Oct;184(10):2641-52
All references(40)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory