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Dclk2 Gene Detail
Summary
  • Symbol
    Dclk2
  • Name
    doublecortin-like kinase 2
  • Synonyms
    6330415M09Rik, Click-II, Dcamkl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918012
    NCBI Gene: 70762
Location & Maps
more
  • Sequence Map
    Chr3:86786151-86920852 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      134702 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 37.88 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DCLK2, doublecortin like kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DCLK2, doublecortin like kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CL2, CLICK2, CLICK-II, CLIK2, DCAMKL2, DCDC3, DCDC3B, DCK2
  • Links
    NCBI Gene ID: 166614
    neXtProt AC: NX_Q8N568

  • Chr Location
    4q31.3; chr4:150078274-150257457 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 69431
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DCLK2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from multigenic genotypes
    11 phenotype references
  • All Mutations and Alleles
    71
  • Chemically induced (other)
    1
  • Gene trapped
    63
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Dclk2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051762 VEGA Gene Model | MGI Sequence Detail 134702 C57BL/6J ±  kb
transcript OTTMUST00000130470 VEGA | MGI Sequence Detail 4012 Not Applicable  
polypeptide OTTMUSP00000069914 VEGA | MGI Sequence Detail 756 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1126 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006311 serine/threonine-protein kinase DCLK2
  • EC
  • InterPro Domains
    IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
    IPR003533 Doublecortin domain
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 18
    cDNA 17
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGI:2139917
References
more
  • Summaries
    All 37
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:228749 Nawabi H, et al., Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron. 2015 Nov 18;88(4):704-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory