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Tspan2
Gene Detail
Symbol

Name
ID
Tspan2
tetraspanin 2
MGI:1917997
Synonyms
6330415F13Rik, B230119D02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
45.25 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:102734529-102801513 bp, + strand
From VEGA annotation of GRCm38

  66985 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21169  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TSPAN2
Protein SuperFamily: tetraspanin
Gene Tree: Tspan2

Human
homologs
TSPAN2, tetraspanin 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10100
neXtProt AC: NX_O60636

Human Synonyms: NET3, TSN2, TSPAN-2

Human Chr (Location): 1p13.2; chr1:115048011-115089500 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice are viable and fertile with mild astrogliosis and microgliosis in the absence of axonal pathology.
 
Interactions
Tspan2 interacts with 371 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process astrocyte development, axon development, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (1)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
cDNA source data(54)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tspan2 ; ZFIN tspan2a    NEW 
Molecular
reagents
All nucleic(54) cDNA(54)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000026566 (Evidence)
Ensembl Gene Model ENSMUSG00000027858 (Evidence)
Entrez Gene 70747 (Evidence)
UniGene 27469
DFCI TC1577958, TC1595140, TC1620194
DoTS DT.101314325, DT.94160544, DT.94160555
NIA Mouse Gene Index U003648
Consensus CDS Project CCDS17688.1, CCDS57249.1
International Mouse Phenotyping Consortium Status Tspan2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026566 VEGA Gene Model | MGI Sequence Detail 66985 C57BL/6J ±  kb
transcript OTTMUST00000065729 VEGA | MGI Sequence Detail 4484 Not Applicable 
polypeptide OTTMUSP00000032795 VEGA | MGI Sequence Detail 221 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(316 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028977 CD81 antigen, large extracellular loop domain
InterPro IPR000301 Tetraspanin
InterPro IPR018503 Tetraspanin, conserved site
InterPro IPR008952 Tetraspanin, EC2 domain
InterPro IPR018499 Tetraspanin/Peripherin
Protein Ontology PR:000016745 tetraspanin-2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:201143 de Monasterio-Schrader P, et al., Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2. Glia. 2013 Nov;61(11):1832-47
All references(33)
Other
accession IDs
MGI:1925095, MGI:2139954

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory