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Nos1ap
Gene Detail
Symbol

Name
ID
Nos1ap
nitric oxide synthase 1 (neuronal) adaptor protein
MGI:1917979
Synonyms
6330408P19Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
76.84 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:170302668-170589861 bp, - strand
From VEGA annotation of GRCm38

  287194 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:135990  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 zebrafish

HCOP human homology predictions: NOS1AP
Gene Tree: Nos1ap

Human
homologs
NOS1AP, nitric oxide synthase 1 (neuronal) adaptor protein
Orthology source: HGNC

IDs:
NCBI Gene ID: 9722
neXtProt AC: NX_O75052

Human Synonyms: 6330408P19Rik, CAPON

Human Chr (Location): 1q23.3; chr1:162069791-162370023 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Nos1ap interacts with 135 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process negative regulation of neuron death, positive regulation of peptidyl-cysteine S-nitrosylation, ...
Component caveola, cytoplasm, ...
Function nitric-oxide synthase binding, PDZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nos1ap    NEW 
Molecular
reagents
All nucleic(7) cDNA(6) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029837 (Evidence)
Ensembl Gene Model ENSMUSG00000038473 (Evidence)
Entrez Gene 70729 (Evidence)
DFCI TC1588286, TC1597349, TC1639519
DoTS DT.55236413, DT.60102405, DT.60103825, DT.97375762
NIA Mouse Gene Index U022037
Consensus CDS Project CCDS48437.1, CCDS48438.1
International Mouse Phenotyping Consortium Status Nos1ap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029837 VEGA Gene Model | MGI Sequence Detail 287194 C57BL/6J ±  kb
transcript OTTMUST00000074045 VEGA | MGI Sequence Detail 3022 Not Applicable 
polypeptide OTTMUSP00000038411 VEGA | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(5) UniProt(5)
Polymorphisms
SNPs within 2kb(4049 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4051)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000011327 carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218359 Treuer AV, et al., NOS1AP modulates intracellular Ca(2+) in cardiac myocytes and is up-regulated in dystrophic cardiomyopathy. Int J Physiol Pathophysiol Pharmacol. 2014;6(1):37-46
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory