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Angptl6 Gene Detail
Summary
  • Symbol
    Angptl6
  • Name
    angiopoietin-like 6
  • Synonyms
    6330404E11Rik, AGF, Angiopoietin-related growth factor, Arp5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917976
    NCBI Gene: 70726
Location & Maps
more
  • Sequence Map
    Chr9:20873809-20879727 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5919 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.66 cM, cytoband A3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ANGPTL6, angiopoietin like 6
  • Vertebrate Orthologs
    6
  • Human Ortholog
    ANGPTL6, angiopoietin like 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGF, ARP5
  • Links
    NCBI Gene ID: 83854
    neXtProt AC: NX_Q8NI99

  • Chr Location
    19p13.2; chr19:10092337-10106209 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Angptl6 mouse models

Human Disease Mouse Models
       Obesity   OMIM: 601665 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    7
  • Targeted
    3
  • Transgenic
    1
  • Incidental Mutations
Most mice homozygous for a knock-out allele die around E13 with cardiovascular defects; survivors develop obesity, lipid accumulation in skeletal muscle and liver, hyperglycemia and hyperinsulinemia, and insulin resistance accompanied by reduced energy expenditure and whole-body oxygen consumption.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042075 VEGA Gene Model | MGI Sequence Detail 5919 C57BL/6J ±  kb
transcript OTTMUST00000110345 VEGA | MGI Sequence Detail 1581 Not Applicable  
polypeptide OTTMUSP00000061534 VEGA | MGI Sequence Detail 457 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    25 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004031 angiopoietin-related protein 6
  • InterPro Domains
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
    IPR020837 Fibrinogen, conserved site
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:157570 Hu M, et al., Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2956-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory