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Angptl6
Gene Detail
 Symbol
Name
ID
Angptl6
angiopoietin-like 6
MGI:1917976
Synonyms 6330404E11Rik, AGF, Angiopoietin-related growth factor, Arp5
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.66 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:20873809-20879727 bp, - strand
From VEGA annotation of GRCm38

  5919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88931  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Angptl6

Human
homologs
Human Homolog ANGPTL6, angiopoietin-like 6
NCBI Gene ID 83854
neXtProt AC  NX_Q8NI99
Human Synonyms  AGF, ARP5
Human Chr (Location)  19p13.2; chr19:10092337-10102888 (-)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Gene trapped(7) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Most mice homozygous for a knock-out allele die around E13 with cardiovascular defects; survivors develop obesity, lipid accumulation in skeletal muscle and liver, hyperglycemia and hyperinsulinemia, and insulin resistance accompanied by reduced energy expenditure and whole-body oxygen consumption.
 
Human Diseases Modeled Using Mouse Angptl6 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process angiogenesis, cell differentiation, ...
Component extracellular region, secretory granule
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042075 (Evidence)
Ensembl Gene ModelENSMUSG00000038742 (Evidence)
Entrez Gene70726 (Evidence)
UniGene34019
DFCITC1584290
DoTSDT.50314994
NIA Mouse Gene IndexU030561
Consensus CDS ProjectCCDS22886.1
International Mouse Knockout Project StatusAngptl6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042075 VEGA Gene Model | MGI Sequence Detail 5919 C57BL/6J ±  kb
transcript OTTMUST00000110345 VEGA | MGI Sequence Detail 1581 Not Applicable 
polypeptide OTTMUSP00000061534 VEGA | MGI Sequence Detail 457 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000004031 angiopoietin-related protein 6
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:157570 Hu M, et al., Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2956-61
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory