About   Help   FAQ
Arhgap45 Gene Detail
Summary
  • Symbol
    Arhgap45
  • Name
    Rho GTPase activating protein 45
  • Synonyms
    6330406L22Rik, Hmha1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917969
    NCBI Gene: 70719
  • Gene Overview
    MyGene.info: ARHGAP45
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80016672-80031471 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917969
protein coding gene Chr10:80016653-80031472 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017478
protein coding gene Chr10:80589570-80606660 (+)
A/J MGP_AJ_G0017456
protein coding gene Chr10:77773730-77789006 (+)
AKR/J MGP_AKRJ_G0017417
protein coding gene Chr10:79891687-79910079 (+)
BALB/cJ MGP_BALBcJ_G0017418
protein coding gene Chr10:78000234-78015713 (+)
C3H/HeJ MGP_C3HHeJ_G0017241
protein coding gene Chr10:79997462-80014477 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017872
protein coding gene Chr10:83373721-83389928 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015560
protein coding gene Chr10:73998474-74013982 (+)
CAST/EiJ MGP_CASTEiJ_G0016808
protein coding gene Chr10:80195940-80211939 (+)
CBA/J MGP_CBAJ_G0017213
protein coding gene Chr10:86600492-86618922 (+)
DBA/2J MGP_DBA2J_G0017319
protein coding gene Chr10:76989531-77004171 (+)
FVB/NJ MGP_FVBNJ_G0017313
protein coding gene Chr10:76168773-76183740 (+)
LP/J MGP_LPJ_G0017390
protein coding gene Chr10:81066834-81083207 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017339
protein coding gene Chr10:88561853-88577285 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017913
protein coding gene Chr10:79879646-79894231 (+)
PWK/PhJ MGP_PWKPhJ_G0016589
protein coding gene Chr10:76856175-76871342 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016378
protein coding gene Chr10:78852946-78869236 (+)
WSB/EiJ MGP_WSBEiJ_G0016868
protein coding gene Chr10:79905161-79922075 (+)



Homology
more
  • Human Ortholog
    ARHGAP45, Rho GTPase activating protein 45
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ARHGAP45, Rho GTPase activating protein 45
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HA-1, HLA-HA1, HMHA1
  • Links
    NCBI Gene ID: 23526
    neXtProt AC: NX_Q92619
    UniProt: Q92619

  • Chr Location
    19p13.3; chr19:1065923-1087831 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70719 NCBI Gene Model | MGI Sequence Detail 14800 C57BL/6J ±  kb
transcript NM_001142701 RefSeq | MGI Sequence Detail 3928 C57BL/6  
polypeptide Q3TBD2 UniProt | EBI | MGI Sequence Detail 1116 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR027267 AH/BAR domain superfamily
    IPR031160 F-BAR domain
    IPR001060 FCH domain
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
Molecular
Reagents
less
  • All nucleic 57
    Genomic 1
    cDNA 56

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143851
References
more
  • Summaries
    All 32
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory