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Dusp16 Gene Detail
Summary
  • Symbol
    Dusp16
  • Name
    dual specificity phosphatase 16
  • Synonyms
    3830417M17Rik, D6Ertd213e, MKP7, MKP-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917936
    NCBI Gene: 70686
  • Gene Overview
    MyGene.info: DUSP16
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:134715468-134792625 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 65.77 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    775 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917936
protein coding gene Chr6:134715468-134792628 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031407
protein coding gene Chr6:138992037-139079611 (-)
A/J MGP_AJ_G0031383
protein coding gene Chr6:133547873-133626642 (-)
AKR/J MGP_AKRJ_G0031310
protein coding gene Chr6:137594814-137674233 (-)
BALB/cJ MGP_BALBcJ_G0031389
protein coding gene Chr6:133361110-133439333 (-)
C3H/HeJ MGP_C3HHeJ_G0031111
protein coding gene Chr6:137642889-137722071 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031849
protein coding gene Chr6:142772733-142861176 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028981
protein coding gene Chr6:132688469-132764804 (-)
CAST/EiJ MGP_CASTEiJ_G0030480
protein coding gene Chr6:137039871-137127852 (-)
CBA/J MGP_CBAJ_G0031070
protein coding gene Chr6:148100018-148191122 (-)
DBA/2J MGP_DBA2J_G0031228
protein coding gene Chr6:132398949-132476728 (-)
FVB/NJ MGP_FVBNJ_G0031178
protein coding gene Chr6:131311284-131389901 (-)
LP/J MGP_LPJ_G0031312
protein coding gene Chr6:139104957-139184093 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031218
protein coding gene Chr6:152138398-152222584 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031882
protein coding gene Chr6:137336903-137418120 (-)
PWK/PhJ MGP_PWKPhJ_G0030205
protein coding gene Chr6:130884533-130966663 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030029
protein coding gene Chr6:135505546-135583477 (-)
WSB/EiJ MGP_WSBEiJ_G0030571
protein coding gene Chr6:137967225-138045552 (-)



Homology
more
  • Human Ortholog
    DUSP16, dual specificity phosphatase 16
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DUSP16, dual specificity phosphatase 16
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MKP7, MKP-7
  • Links
    NCBI Gene ID: 80824
    neXtProt AC: NX_Q9BY84
    UniProt: Q9BY84

  • Chr Location
    12p13.2; chr12:12473282-12562839 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 15604
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DUSP16
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit complete neonatal lethality and decreased birth weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030203 Ensembl Gene Model | MGI Sequence Detail 77158 C57BL/6J ±  kb
    transcript ENSMUST00000100857 Ensembl | MGI Sequence Detail 5104 Not Applicable  
    polypeptide ENSMUSP00000098419 Ensembl | MGI Sequence Detail 660 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR024950 Dual specificity phosphatase
      IPR000340 Dual specificity phosphatase, catalytic domain
      IPR020422 Dual specificity protein phosphatase domain
      IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR029021 Protein-tyrosine phosphatase-like
      IPR001763 Rhodanese-like domain
      IPR036873 Rhodanese-like domain superfamily
      IPR000387 Tyrosine specific protein phosphatases domain
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 19
      Primer pair 5
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1098836, MGI:2141715
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:251744 Zega K, et al., Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool. Front Mol Neurosci. 2017;10:372

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory