Clic5
Gene Detail

Symbol Name ID

Clic5 chloride intracellular channel 5 MGI:1917912

Synonyms

5730531E12Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 17

20.53 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:44188572-44280168 bp, + strand From NCBI annotation of GRCm38   91597 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:987  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: chloride intracellular channel protein
Gene Tree: Clic5

Human homologs

Human Homolog		CLIC5, chloride intracellular channel 5
NCBI Gene ID		53405
neXtProt AC		NX_Q9NZA1
Human Synonyms		MST130, MSTP130
Human Chr (Location)		6p12.3; chr6:45866188-46048085 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Spontaneous(1)
 

Mice homozygous for a spontaneous mutation exhibit head bobbing and circling behavior, inability to swim, and complete deafness by 7-8 months of age caused by dysmorphic stereocilia and progressive hair cell degeneration.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	auditory receptor cell stereocilium organization, chloride transport, ...
Component	actin cytoskeleton, chloride channel complex, ...
Function	chloride channel activity, voltage-gated chloride channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (160)    Tissues (88)    Images (23)
Theiler Stages: 23, 24, 28

Assay Type	Results
Immunohistochemistry	15
RNA in situ	123
Northern blot	3
Western blot	6
RT-PCR	13

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) cDNA(41) Primer pair(5)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000023959 (Evidence)
Entrez Gene	224796 (Evidence)
UniGene	37666
DFCI	TC1583540, TC1618803
DoTS	DT.526057, DT.91350468
NIA Mouse Gene Index	U043605
Consensus CDS Project	CCDS28804.1
International Mouse Knockout Project Status	Clic5

Sequences

Length	Strain/Species
genomic	224796	NCBI Gene Model | MGI Sequence Detail	91597	C57BL/6J
transcript	NM_172621	RefSeq | MGI Sequence Detail	5870	NOD
polypeptide	Q8BXK9	UniProt | EBI | MGI Sequence Detail	251	Not Applicable

All sequences(28) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(174 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017933	Glutathione S-transferase/chloride channel, C-terminal
InterPro	IPR010987	Glutathione S-transferase, C-terminal-like
InterPro	IPR002946	Intracellular chloride channel
InterPro	IPR012336	Thioredoxin-like fold
Protein Ontology	PR:000005578	chloride intracellular channel protein 5

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:177885 Brunskill EW, et al., Defining the molecular character of the developing and adult kidney podocyte. PLoS One. 2011;6(9):e24640
All references(37)

Other accession IDs

MGI:2667335