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Clic5
Gene Detail
 Symbol
Name
ID
Clic5
chloride intracellular channel 5
MGI:1917912
Synonyms 5730531E12Rik
Feature Type protein coding gene
Genetic Map
Chromosome 17
20.53 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:44188572-44280168 bp, + strand
From NCBI annotation of GRCm38

  91597 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:987  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: chloride intracellular channel protein
Gene Tree: Clic5

Human
homologs
Human Homolog CLIC5, chloride intracellular channel 5
NCBI Gene ID 53405
neXtProt AC  NX_Q9NZA1
Human Synonyms  MST130, MSTP130
Human Chr (Location)  6p12.3; chr6:45898451-46080348 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Spontaneous(1)
 
Mice homozygous for a spontaneous mutation exhibit head bobbing and circling behavior, inability to swim, and complete deafness by 7-8 months of age caused by dysmorphic stereocilia and progressive hair cell degeneration.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process auditory receptor cell stereocilium organization, chloride transmembrane transport, ...
Component actin cytoskeleton, chloride channel complex, ...
Function chloride channel activity, voltage-gated chloride channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (189)    Tissues (110)    Images (26)
Theiler Stages: 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 15
RNA in situ 152
Northern blot 3
Western blot 6
RT-PCR 13
cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(46) cDNA(41) Primer pair(5)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000023959 (Evidence)
Entrez Gene224796 (Evidence)
UniGene37666
DFCITC1583540, TC1618803
DoTSDT.526057, DT.91350468
NIA Mouse Gene IndexU043605
Consensus CDS ProjectCCDS28804.1
International Mouse Knockout Project StatusClic5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 224796 NCBI Gene Model | MGI Sequence Detail 91597 C57BL/6J ±  kb
transcript NM_172621 RefSeq | MGI Sequence Detail 5870 NOD 
polypeptide Q8BXK9 UniProt | EBI | MGI Sequence Detail 251 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(756 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010987 Glutathione S-transferase, C-terminal-like
InterPro IPR004045 Glutathione S-transferase, N-terminal
InterPro IPR002946 Intracellular chloride channel
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000005578 chloride intracellular channel protein 5
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:177885 Brunskill EW, et al., Defining the molecular character of the developing and adult kidney podocyte. PLoS One. 2011;6(9):e24640
All references(38)
Other
accession IDs
MGI:2667335

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory