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Clic5
Gene Detail
Symbol

Name
ID
Clic5
chloride intracellular channel 5
MGI:1917912
Synonyms
5730531E12Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
20.53 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:44188572-44280168 bp, + strand
From Ensembl annotation of GRCm38

  91597 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:987  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CLIC5
Protein SuperFamily: chloride intracellular channel protein
Gene Tree: Clic5

Human
homologs
CLIC5, chloride intracellular channel 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 53405
neXtProt AC: NX_Q9NZA1

Human Synonyms: DFNB102, DFNB103, MST130, MSTP130

Human Chr (Location): 6p12.3; chr6:45898451-46080348 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CLIC5

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a spontaneous mutation exhibit head bobbing and circling behavior, inability to swim, and complete deafness by 7-8 months of age caused by dysmorphic stereocilia and progressive hair cell degeneration.
 
Interactions
Clic5 interacts with 425 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (189)    Tissues (118)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 152
Northern blot 3
Western blot 6
RT-PCR 13
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase clic5 ; ZFIN clic5b    NEW 
Molecular
reagents
All nucleic(46) cDNA(41) Primer pair(5)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000023959 (Evidence)
Entrez Gene 224796 (Evidence)
UniGene 37666
DFCI TC1583540, TC1618803
DoTS DT.526057, DT.91350468
NIA Mouse Gene Index U043605
Consensus CDS Project CCDS28804.1
International Mouse Phenotyping Consortium Status Clic5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023959 Ensembl Gene Model | MGI Sequence Detail 91597 C57BL/6J ±  kb
transcript ENSMUST00000024755 Ensembl | MGI Sequence Detail 5870 Not Applicable 
polypeptide ENSMUSP00000024755 Ensembl | MGI Sequence Detail 251 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(756 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR030264 Chloride intracellular channel protein 5
InterPro IPR010987 Glutathione S-transferase, C-terminal-like
InterPro IPR004045 Glutathione S-transferase, N-terminal
InterPro IPR002946 Intracellular chloride channel
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000005578 chloride intracellular channel protein 5
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218280 Al-Momany A, et al., Clustered PI(4,5)P(2) accumulation and ezrin phosphorylation in response to CLIC5A. J Cell Sci. 2014 Dec 15;127(24):5164-78
All references(38)
Other
accession IDs
MGI:2667335

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory