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Dcp2
Gene Detail
Symbol

Name
ID
Dcp2
DCP2 decapping enzyme homolog (S. cerevisiae)
MGI:1917890
Synonyms
2410015D23Rik, 5730537H01Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 18
23.74 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:44380500-44424969 bp, + strand
From NCBI annotation of GRCm38

  44470 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13968  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: mRNA-decapping enzyme 2
Gene Tree: Dcp2

Human
homologs
Human Homolog DCP2, decapping mRNA 2
NCBI Gene ID 167227
neXtProt AC  NX_Q8IU60
Human Synonyms  NUDT20
Human Chr (Location)  5q22.2; chr5:112976702-113022195 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(205) : Gene trapped(203) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele are viable and fertile.
 
Interactions
Dcp2 interacts with 507 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process histone mRNA catabolic process, mRNA catabolic process, ...
Component cytoplasm, cytoplasmic mRNA processing body, ...
Function hydrolase activity, m7G(5')pppN diphosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (39)    Tissues (19)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 39
cDNA source data(93)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(94) cDNA(93) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024472 (Evidence)
Entrez Gene70640 (Evidence)
UniGene87629
DFCITC1584029, TC1667576, TC1680053
DoTSDT.40182707, DT.533093, DT.91327691
NIA Mouse Gene IndexU040836
EC3.6.1.62
Consensus CDS ProjectCCDS50275.1
International Mouse Knockout Project StatusDcp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 70640 NCBI Gene Model | MGI Sequence Detail 44470 C57BL/6J ±  kb
transcript NM_027490 RefSeq | MGI Sequence Detail 8643 C57BL/6 
polypeptide Q9CYC6 UniProt | EBI | MGI Sequence Detail 422 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(465 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007722 mRNA decapping protein 2, Box A
InterPro IPR020084 NUDIX hydrolase, conserved site
InterPro IPR000086 NUDIX hydrolase domain
InterPro IPR015797 NUDIX hydrolase domain-like
Protein Ontology PR:000006319 m7GpppN-mRNA hydrolase
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193990 Ma J, et al., Maternally recruited DCP1A and DCP2 contribute to messenger RNA degradation during oocyte maturation and genome activation in mouse. Biol Reprod. 2013 Jan;88(1):11
All references(39)
Other
accession IDs
MGI:1913674, MGI:3035096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory