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Dcp2
Gene Detail
Symbol

Name
ID
Dcp2
DCP2 decapping enzyme homolog (S. cerevisiae)
MGI:1917890
Synonyms
2410015D23Rik, 5730537H01Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 18
23.74 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:44380502-44424969 bp, + strand
From VEGA annotation of GRCm38

  44468 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13968  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: DCP2
Protein SuperFamily: mRNA-decapping enzyme 2
Gene Tree: Dcp2

Human
homologs
DCP2, decapping mRNA 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 167227
neXtProt AC: NX_Q8IU60

Human Synonyms: NUDT20

Human Chr (Location): 5q22.2; chr5:112976702-113022195 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(206) : Gene trapped(203) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele are viable and fertile.
 
Interactions
Dcp2 interacts with 506 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (39)    Tissues (19)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 39
cDNA source data(93)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dcp2 ; ZFIN dcp2    NEW 
Molecular
reagents
All nucleic(94) cDNA(93) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000055564 (Evidence)
Ensembl Gene Model ENSMUSG00000024472 (Evidence)
Entrez Gene 70640 (Evidence)
UniGene 87629
DFCI TC1584029, TC1667576, TC1680053
DoTS DT.40182707, DT.533093, DT.91327691
NIA Mouse Gene Index U040836
EC 3.6.1.62
Consensus CDS Project CCDS50275.1
International Mouse Phenotyping Consortium Status Dcp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055564 VEGA Gene Model | MGI Sequence Detail 44468 C57BL/6J ±  kb
transcript OTTMUST00000137521 VEGA | MGI Sequence Detail 8616 Not Applicable 
polypeptide OTTMUSP00000072413 VEGA | MGI Sequence Detail 422 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(465 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007722 mRNA decapping protein 2, Box A
InterPro IPR020084 NUDIX hydrolase, conserved site
InterPro IPR000086 NUDIX hydrolase domain
InterPro IPR015797 NUDIX hydrolase domain-like
Protein Ontology PR:000006319 m7GpppN-mRNA hydrolase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193990 Ma J, et al., Maternally recruited DCP1A and DCP2 contribute to messenger RNA degradation during oocyte maturation and genome activation in mouse. Biol Reprod. 2013 Jan;88(1):11
All references(42)
Other
accession IDs
MGI:1913674, MGI:3035096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory