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Ankrd26
Gene Detail
Symbol

Name
ID
Ankrd26
ankyrin repeat domain 26
MGI:1917887
Synonyms
5730521P14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
55.86 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:118501308-118562226 bp, - strand
From VEGA annotation of GRCm38

  60919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45968  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: ANKRD26
Gene Tree: Ankrd26

Human
homologs
ANKRD26, ankyrin repeat domain 26
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 22852
neXtProt AC: NX_Q9UPS8

Human Synonyms: bA145E8.1, THC2

Human Chr (Location): 10p12.1; chr10:26966584-27100498 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ANKRD26

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele have enlarged kidneys and hearts, exhibit increased lean body mass and adiposity, develop extreme obesity associated with hyperphagia rather than reduced energy expenditure, and show insulin resistance and gigantism.
 
Human Diseases Modeled in Mice Using Ankrd26 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Ankrd26 interacts with 103 markers (Mir18, Mir18b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process glucose homeostasis, negative regulation of ERK1 and ERK2 cascade, ...
Component actin filament, centrosome
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ankrd7    NEW 
Molecular
reagents
All nucleic(51) cDNA(51)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000048361 (Evidence)
Ensembl Gene Model ENSMUSG00000007827 (Evidence)
Entrez Gene 232339 (Evidence)
UniGene 276116
DFCI TC1588111, TC1726274, TC1629570, TC1598200, TC1605996
DoTS DT.55147108, DT.94204180, DT.91412123
NIA Mouse Gene Index U027792
Consensus CDS Project CCDS39609.1
International Mouse Phenotyping Consortium Status Ankrd26
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048361 VEGA Gene Model | MGI Sequence Detail 60919 C57BL/6J ±  kb
transcript OTTMUST00000124022 VEGA | MGI Sequence Detail 6930 Not Applicable 
polypeptide OTTMUSP00000067567 VEGA | MGI Sequence Detail 1681 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(734 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR021885 Protein of unknown function DUF3496
Protein Ontology PR:000032570 ankyrin repeat domain-containing protein 26
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:178128 Raciti GA, et al., Partial inactivation of Ankrd26 causes diabetes with enhanced insulin responsiveness of adipose tissue in mice. Diabetologia. 2011 Nov;54(11):2911-22
All references(33)
Disease annotation references (1)
Other
accession IDs
MGI:2448538

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory