Ankrd26
Gene Detail

Symbol Name ID

Ankrd26 ankyrin repeat domain 26 MGI:1917887

Synonyms

5730521P14Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 6

55.86 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:118502564-118562256 bp, - strand From NCBI annotation of GRCm38   59693 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:45968  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ankrd26

Human homologs

Human Homolog		ANKRD26, ankyrin repeat domain 26
NCBI Gene ID		22852
neXtProt AC		NX_Q9UPS8
Human Synonyms		bA145E8.1, THC2
Human Chr (Location)		10p12.1; chr10:27293045-27389427 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ANKRD26

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)
 

Mice homozygous for a gene trapped allele have enlarged kidneys and hearts, exhibit increased lean body mass and adiposity, develop extreme obesity associated with hyperphagia rather than reduced energy expenditure, and show insulin resistance and gigantism.

 
Human Diseases Modeled Using Mouse Ankrd26 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	glucose homeostasis, negative regulation of ERK1 and ERK2 cascade, ...
Component	actin filament, centrosome
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(51) cDNA(51)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000007827 (Evidence)
Entrez Gene	232339 (Evidence)
UniGene	276116
DFCI	TC1588111, TC1598200, TC1605996, TC1629570, TC1726274
DoTS	DT.55147108, DT.91412123, DT.94204180
NIA Mouse Gene Index	U027792
Consensus CDS Project	CCDS39609.1
International Mouse Knockout Project Status	Ankrd26

Sequences

Length	Strain/Species
genomic	232339	NCBI Gene Model | MGI Sequence Detail	59693	C57BL/6J
transcript	NM_001081112	RefSeq | MGI Sequence Detail	5704	Not Specified
polypeptide	Q811D2	UniProt | EBI | MGI Sequence Detail	1581	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(480 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR021885	Protein of unknown function DUF3496
Protein Ontology	PR:000032570	ankyrin repeat domain-containing protein 26

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:178128 Raciti GA, et al., Partial inactivation of Ankrd26 causes diabetes with enhanced insulin responsiveness of adipose tissue in mice. Diabetologia. 2011 Nov;54(11):2911-22
All references(33)

Other accession IDs

MGI:2448538