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Ssfa2 Gene Detail
Summary
  • Symbol
    Ssfa2
  • Name
    sperm specific antigen 2
  • Synonyms
    CS1, CS-1, KRAP, mKIAA1927, SPAG13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917849
    NCBI Gene: 70599
  • Gene Overview
    MyGene.info: SSFA2
Location & Maps
more
  • Sequence Map
    Chr2:79635352-79672966 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      37615 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 47.58 cM, cytoband D
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SSFA2, sperm specific antigen 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SSFA2, sperm specific antigen 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CS1, CS-1, KRAP, SPAG13
  • Links
    NCBI Gene ID: 6744
    neXtProt AC: NX_P28290

  • Chr Location
    2q31.3; chr2:181891716-181930738 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 4912
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SSFA2
  • Gene Tree
    Ssfa2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 1 allele in 2 genetic backgrounds
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    4
  • Genomic Mutations
    3 involving Ssfa2
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for a null mutation display decreased body weight, resistance to diet induced obesity, increased food intake, decreased adipose tissue mass, elevated metabolic rate, abnormal glucose homeostasis, and abnormal hormone levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    100
  • Other Mouse Links
    GEO
  • Other Vertebrate Links
    Xenbase ssfa2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013318 VEGA Gene Model | MGI Sequence Detail 37615 C57BL/6J ±  kb
transcript OTTMUST00000032211 VEGA | MGI Sequence Detail 5168 Not Applicable  
polypeptide OTTMUSP00000014318 VEGA | MGI Sequence Detail 1252 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    309 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000015652 sperm-specific antigen 2
  • InterPro Domains
    IPR029325 IP3R-interacting domain
    IPR026648 Sperm-specific antigen 2
    IPR029326 Sperm-specific antigen 2, C-terminal
Molecular
Reagents
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  • All nucleic 100
    cDNA 100

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory