Itprid2 Gene Detail

Summary

• Symbol
  Itprid2
• Name
  ITPR interacting domain containing 2
• Synonyms
  CS1, CS-1, KRAP, mKIAA1927, SPAG13, Ssfa2

• Feature Type
  protein coding gene
• IDs
  MGI:1917849
  NCBI Gene: 70599
• Gene Overview
  MyGene.info: ITPRID2
• Alliance
  gene page
• Transcription Start Sites
  9 TSS

Location &
Maps

• Sequence Map
  Chr2:79635352-79672966 bp, + strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 47.58 cM, cytoband D
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  309 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917849	protein coding gene	Chr2:79635260-79672966 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0025879	protein coding gene	Chr2:80191667-80230530 (+)
A/J	MGP_AJ_G0025856	protein coding gene	Chr2:77091355-77128919 (+)
AKR/J	MGP_AKRJ_G0025825	protein coding gene	Chr2:79100597-79138117 (+)
BALB/cJ	MGP_BALBcJ_G0025852	protein coding gene	Chr2:77215838-77253591 (+)
C3H/HeJ	MGP_C3HHeJ_G0025611	protein coding gene	Chr2:79333154-79371554 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026298	protein coding gene	Chr2:82557776-82596487 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023701	protein coding gene	Chr2:74340629-74378582 (+)
CAST/EiJ	MGP_CASTEiJ_G0025073	protein coding gene	Chr2:79756150-79796322 (+)
CBA/J	MGP_CBAJ_G0025592	protein coding gene	Chr2:85519913-85562591 (+)
DBA/2J	MGP_DBA2J_G0025723	protein coding gene	Chr2:76640199-76677304 (+)
FVB/NJ	MGP_FVBNJ_G0025685	protein coding gene	Chr2:76007193-76044604 (+)
LP/J	MGP_LPJ_G0025811	protein coding gene	Chr2:80031417-80068873 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025716	protein coding gene	Chr2:87380168-87424892 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026354	protein coding gene	Chr2:79276752-79319032 (+)
PWK/PhJ	MGP_PWKPhJ_G0024816	protein coding gene	Chr2:76585934-76627833 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024622	protein coding gene	Chr2:79548063-79585550 (+)
WSB/EiJ	MGP_WSBEiJ_G0025142	protein coding gene	Chr2:79902643-79940561 (+)

Homology

• Human Ortholog
  ITPRID2, ITPR interacting domain containing 2

• Vertebrate Orthologs
  10

• Human Ortholog
  ITPRID2, ITPR interacting domain containing 2
  Orthology source: HomoloGene, HGNC
• Synonyms
  CS1, CS-1, KRAP, SPAG13, SSFA2
• Links
  HGNC:11319

  NCBI Gene ID: 6744

  neXtProt AC: NX_P28290

  UniProt: P28290

  
  
• Chr Location
  2q31.3; chr2:181891716-181930738 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 4912
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: ITPRID2
• Gene Tree
  Itprid2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  27 phenotypes from 1 allele in 2 genetic backgrounds
  2 images
  10 phenotype references
  

• All Mutations and Alleles
  9
• Chemically induced (other)
  1
• Gene trapped
  4
• Targeted
  4
• Genomic Mutations
  3 involving Itprid2
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  23 strains or lines available

Mice homozygous for a null mutation display decreased body weight, resistance to diet induced obesity, increased food intake, decreased adipose tissue mass, elevated metabolic rate, abnormal glucose homeostasis, and abnormal hormone levels.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  7
• GO References
  3

• External Resources
  FuncBase

Expression

• cDNA Data
  100

• Other Mouse Links
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase itprid2

Interactions

• Itprid2 interacts with 282 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  52
• RefSeq
  5
• UniProt
  4
• CCDS
  CCDS16170.1
• UniGene
  272881

• Ensembl
  ENSMUSG00000027007 (Evidence)
• NCBI Gene
  70599

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000027007	Ensembl Gene Model | MGI Sequence Detail	37615	C57BL/6J
transcript	ENSMUST00000111785	Ensembl | MGI Sequence Detail	5168	Not Applicable
polypeptide	ENSMUSP00000107415	Ensembl | MGI Sequence Detail	1252	Not Applicable

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000015652 sperm-specific antigen 2
  (term hierarchy)
• InterPro Domains
  IPR029325 ITPR-interacting domain
  IPR026648 Protein ITPRID2
  IPR029326 Sperm-specific antigen 2, C-terminal

Molecular
Reagents

• All nucleic 100

  cDNA 100

  
  

  Microarray probesets 3

References

• Summaries
  All 35

  Gene Ontology 3

  Phenotypes 10
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:227263 Fabre PJ, et al., Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13964-9

TSS for Itprid2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18584	Chr2:79635270-79635290 (+)	-72 bp
Tssr18585	Chr2:79635300-79635320 (+)	-42 bp
Tssr18586	Chr2:79635370-79635410 (+)	38 bp
Tssr18587	Chr2:79635416-79635441 (+)	77 bp
Tssr18588	Chr2:79635444-79635463 (+)	102 bp
Tssr18589	Chr2:79635599-79635650 (+)	273 bp
Tssr18590	Chr2:79635654-79635671 (+)	311 bp
Tssr18591	Chr2:79639194-79639207 (+)	3,849 bp
Tssr18592	Chr2:79644526-79644551 (+)	9,187 bp