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Fam213a Gene Detail
Summary
  • Symbol
    Fam213a
  • Name
    family with sequence similarity 213, member A
  • Synonyms
    5730469M10Rik, Adiporedoxin, Adrx
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917814
    NCBI Gene: 70564
  • Gene Overview
    MyGene.info: PRXL2A
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:40993740-41013788 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 22.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917814
protein coding gene Chr14:40993732-41013833 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021193
protein coding gene Chr14:34627347-34647421 (-)
A/J MGP_AJ_G0021141
protein coding gene Chr14:33278785-33298829 (-)
AKR/J MGP_AKRJ_G0021118
protein coding gene Chr14:34645300-34665341 (-)
BALB/cJ MGP_BALBcJ_G0021145
protein coding gene Chr14:33496372-33516800 (-)
C3H/HeJ MGP_C3HHeJ_G0020928
protein coding gene Chr14:34598854-34619118 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021577
protein coding gene Chr14:36018698-36038858 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019139
protein coding gene Chr14:32911365-32931751 (-)
CAST/EiJ MGP_CASTEiJ_G0020453
protein coding gene Chr14:34373495-34393528 (-)
CBA/J MGP_CBAJ_G0020894
protein coding gene Chr14:37236366-37259680 (-)
DBA/2J MGP_DBA2J_G0021017
protein coding gene Chr14:33237898-33258850 (-)
FVB/NJ MGP_FVBNJ_G0021001
protein coding gene Chr14:33174578-33194676 (-)
LP/J MGP_LPJ_G0021086
protein coding gene Chr14:34863981-34883989 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021027
protein coding gene Chr14:36874278-36894379 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021610
protein coding gene Chr14:34427374-34447449 (-)
PWK/PhJ MGP_PWKPhJ_G0020201
protein coding gene Chr14:32714144-32734483 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020025
protein coding gene Chr14:34056531-34076898 (-)
WSB/EiJ MGP_WSBEiJ_G0020508
protein coding gene Chr14:34535903-34556063 (-)



Homology
more
  • Human Ortholog
    PRXL2A, peroxiredoxin like 2A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRXL2A, peroxiredoxin like 2A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Adrx, C10orf58, FAM213A, PAMM
  • Links
    NCBI Gene ID: 84293
    neXtProt AC: NX_Q9BRX8
    UniProt: Q9BRX8

  • Chr Location
    10q23.1; chr10:80407829-80437115 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced circulating adipokine levels and decreased collagen deposition in adipose tissue along with mild adipocyte ER stress and hyperinsulinemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021792 Ensembl Gene Model | MGI Sequence Detail 20049 C57BL/6J ±  kb
    transcript ENSMUST00000118466 Ensembl | MGI Sequence Detail 1567 Not Applicable  
    polypeptide ENSMUSP00000112377 Ensembl | MGI Sequence Detail 229 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR032802 Peroxiredoxin-like FAM213A
      IPR032801 Peroxiredoxin-like FAM213/AAED1
      IPR036249 Thioredoxin-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 78

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145754
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 4
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:234040 Jedrychowski MP, et al., Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab. 2015 Nov;4(11):758-70

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory