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Qpct Gene Detail
Summary
  • Symbol
    Qpct
  • Name
    glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
  • Synonyms
    5730422A13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917786
    NCBI Gene: 70536
  • Gene Overview
    MyGene.info: QPCT
Location & Maps
more
  • Sequence Map
    Chr17:79051906-79090243 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38338 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 49.83 cM, cytoband E3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    QPCT, glutaminyl-peptide cyclotransferase
  • Vertebrate Orthologs
    12
  • Human Ortholog
    QPCT, glutaminyl-peptide cyclotransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GCT, QC, sQC
  • Links
    NCBI Gene ID: 25797
    neXtProt AC: NX_Q16769

  • Chr Location
    2p22.2; chr2:37344610-37373322 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8238
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;2 frog, western clawed
  • HCOP
    human homology predictions: QPCT
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    7 phenotype references
  • All Mutations and Alleles
    5
  • Gene trapped
    2
  • Targeted
    2
  • Transgenic
    1
  • Incidental Mutations
Mice exhibit normal motor coordination and spatial working memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024084 Ensembl Gene Model | MGI Sequence Detail 38338 C57BL/6J ±  kb
transcript ENSMUST00000040789 Ensembl | MGI Sequence Detail 1924 Not Applicable  
polypeptide ENSMUSP00000038732 Ensembl | MGI Sequence Detail 362 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    569 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 27
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:176575 Alexandru A, et al., Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A{beta} Is Induced by Pyroglutamate-A{beta} Formation. J Neurosci. 2011 Sep 7;31(36):12790-12801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory