About   Help   FAQ
Qpct
Gene Detail
Symbol

Name
ID
Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
MGI:1917786
Synonyms
5730422A13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
49.83 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:79051906-79090243 bp, + strand
From Ensembl annotation of GRCm38

  38338 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8238  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 2 zebrafish

HCOP human homology predictions: QPCT
Gene Tree: Qpct

Human
homologs
QPCT, glutaminyl-peptide cyclotransferase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 25797
neXtProt AC: NX_Q16769

Human Synonyms: GCT, QC, sQC

Human Chr (Location): 2p22.2; chr2:37344610-37373322 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice exhibit normal motor coordination and spatial working memory.
 
Interactions
Qpct interacts with 80 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Expression
Literature Summary: (2 records)
Data Summary: Results (135)    Tissues (99)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 135
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA QPCT ; Xenbase qpct    NEW 
Molecular
reagents
All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024084 (Evidence)
Entrez Gene 70536 (Evidence)
UniGene 293870
DFCI TC1577636, TC1592367
DoTS DT.101369871, DT.50315539
NIA Mouse Gene Index U018243
EC 2.3.2.5
PDB 3SI2, 3SI1
Consensus CDS Project CCDS28983.1
International Mouse Phenotyping Consortium Status Qpct
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024084 Ensembl Gene Model | MGI Sequence Detail 38338 C57BL/6J ±  kb
transcript ENSMUST00000040789 Ensembl | MGI Sequence Detail 1924 Not Applicable 
polypeptide ENSMUSP00000038732 Ensembl | MGI Sequence Detail 362 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(5) UniProt(3)
Polymorphisms
SNPs within 2kb(581 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007484 Peptidase M28
Protein Ontology PR:000013565 glutaminyl-peptide cyclotransferase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:176575 Alexandru A, et al., Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A{beta} Is Induced by Pyroglutamate-A{beta} Formation. J Neurosci. 2011 Sep 7;31(36):12790-12801
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory