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Lrfn2
Gene Detail
 Symbol
Name
ID
Lrfn2
leucine rich repeat and fibronectin type III domain containing 2
MGI:1917780
Synonyms 5730420O05Rik, mKIAA1246, SALM1
Feature Type protein coding gene
Genetic Map
Chromosome 17
24.66 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:48932379-49097588 bp, + strand
From VEGA annotation of GRCm38

  165210 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19182  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lrfn2

Human
homologs
Human Homolog LRFN2, leucine rich repeat and fibronectin type III domain containing 2
NCBI Gene ID 57497
neXtProt AC  NX_Q9ULH4
Human Synonyms  FIGLER2, KIAA1246, SALM1
Human Chr (Location)  6p21.2-p21.1; chr6:40391634-40587387 (-)  GRCh38
Alleles
and
phenotypes
All alleles(11) : Targeted(1) Gene trapped(9) Transgenic(1)
 
Mice homozygous for a transgenic gene disruption exhibit small spleens, small or no thymi, impaired T cell development, and decreased T cell proliferation in response to mitogen.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Component cell junction, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (106)    Tissues (88)    Images (17)
Theiler Stages: 6, 8, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 71
Northern blot 35
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) cDNA(8) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000014931 (Evidence)
Ensembl Gene ModelENSMUSG00000040490 (Evidence)
Entrez Gene70530 (Evidence)
UniGene133607
DFCITC1582911
DoTSDT.55201748
NIA Mouse Gene IndexU018084
Consensus CDS ProjectCCDS28871.1
International Mouse Knockout Project StatusLrfn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014931 VEGA Gene Model | MGI Sequence Detail 165210 C57BL/6J ±  kb
transcript OTTMUST00000035461 VEGA | MGI Sequence Detail 3202 Not Applicable 
polypeptide OTTMUSP00000015873 VEGA | MGI Sequence Detail 788 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(815 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000030703 leucine-rich repeat and fibronectin type-III domain-containing protein 2
References (Earliest) J:126456 Badiani P, et al., Dominant interfering alleles define a role for c-Myb in T-cell development. Genes Dev. 1994 Apr 1;8(7):770-82
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory