About   Help   FAQ
Glipr2 Gene Detail
Summary
  • Symbol
    Glipr2
  • Name
    GLI pathogenesis-related 2
  • Synonyms
    5730414A08Rik, GAPR-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917770
    NCBI Gene: 384009
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43957702-43979118 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.07 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917770
 protein coding gene Chr4:43957401-43979118 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028229
 protein coding gene Chr4:42090693-42111853 (+)
A/J MGP_AJ_G0028186
 protein coding gene Chr4:40599354-40621287 (+)
AKR/J MGP_AKRJ_G0028138
 protein coding gene Chr4:41550880-41576222 (+)
BALB/cJ MGP_BALBcJ_G0028206
 protein coding gene Chr4:40696388-40718182 (+)
C3H/HeJ MGP_C3HHeJ_G0027928
 protein coding gene Chr4:42164303-42188234 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028647
 protein coding gene Chr4:43697927-43726076 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025957
 protein coding gene Chr4:38035262-38056451 (+)
CAST/EiJ MGP_CASTEiJ_G0027367
 protein coding gene Chr4:41682328-41706583 (+)
CBA/J MGP_CBAJ_G0027894
 protein coding gene Chr4:45046876-45073053 (+)
DBA/2J MGP_DBA2J_G0028043
 protein coding gene Chr4:40510157-40531568 (+)
FVB/NJ MGP_FVBNJ_G0028010
 protein coding gene Chr4:39741789-39762836 (+)
LP/J MGP_LPJ_G0028142
 protein coding gene Chr4:42170278-42195423 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028034
 protein coding gene Chr4:48248711-48274877 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028683
 protein coding gene Chr4:41763392-41786915 (+)
PWK/PhJ MGP_PWKPhJ_G0027091
 protein coding gene Chr4:40557798-40579275 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026920
 protein coding gene Chr4:41290175-41311256 (+)
WSB/EiJ MGP_WSBEiJ_G0027445
 protein coding gene Chr4:41639715-41664544 (+)



Homology
more
  • Human Ortholog
    GLIPR2, GLI pathogenesis related 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLIPR2, GLI pathogenesis related 2
  • Synonyms
    C9orf19, GAPR1, GAPR-1
  • Links
    NCBI Gene ID: 152007
    neXtProt AC: NX_Q9H4G4
    UniProt: Q9H4G4

  • Chr Location
    9p13.3; chr9:36136536-36163913 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    10 phenotype references
Mice homozygous for a null allele exhibit increased autophagy due to increased autophagic flux.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    22
  • cDNA Data
    42
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 384009 NCBI Gene Model | MGI Sequence Detail 21417 C57BL/6J ±  kb
transcript NM_027450 RefSeq | MGI Sequence Detail 2019 C57BL/6  
polypeptide Q9CYL5 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    Genomic 1
    cDNA 42
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2140653
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:312370 Zhao Y, et al., GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex. Autophagy. 2021 Oct;17(10):2891-2904
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory