Wdr77 MGI Mouse Gene Detail - MGI:1917715

Symbol

Wdr77
Name

WD repeat domain 77
Synonyms

2610003I18Rik, 2610312E17Rik, p44/MEP50

Feature Type

protein coding gene
IDs

MGI:1917715
NCBI Gene: 70465
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr3:105866814-105877076 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 46.46 cM
Mapping Data

2 experiments

SNPs within 2kb

397 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917715	protein coding gene	Chr3:105866685-105877353 (+)
129S1/SvImJ	ENSMUSG00200034636	protein coding gene	Chr3:102466280-102476671 (+)
A/J	ENSMUSG00195024675	protein coding gene	Chr3:102889739-102900126 (+)
AKR/J	ENSMUSG00220027953	protein coding gene	Chr3:101258611-101269002 (+)
BALB/cJ	ENSMUSG00180017250	protein coding gene	Chr3:102831907-102842298 (+)
C3H/HeJ	ENSMUSG00175026794	protein coding gene	Chr3:102369986-102380373 (+)
C57BL/6NJ	ENSMUSG00215028896	protein coding gene	Chr3:103139219-103149611 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025481	protein coding gene	Chr3:99988520-99999099 (+)
CAST/EiJ	ENSTCUG00005019974	protein coding gene	Chr3:103098262-103108608 (+)
CBA/J	ENSMUSG00210007220	protein coding gene	Chr3:102991946-103002333 (+)
DBA/2J	ENSMUSG00185020337	protein coding gene	Chr3:103473104-103483495 (+)
FVB/NJ	ENSMUSG00205016846	protein coding gene	Chr3:102042965-102053356 (+)
JF1/MsJ	ENSUMUG00000002527	protein coding gene	Chr3:102215296-102225642 (+)
LP/J	ENSMUSG00230013863	protein coding gene	Chr3:105394173-105404564 (+)
NOD/ShiLtJ	ENSMUSG00190035017	protein coding gene	Chr3:103677916-103688307 (+)
NZO/HlLtJ	ENSMUSG00225018995	protein coding gene	Chr3:107877107-107887641 (+)
PWK/PhJ	ENSLUMG00010026792	protein coding gene	Chr3:102287231-102297620 (+)
SPRET/EiJ	ENSMSPG00010031208	protein coding gene	Chr3:102477321-102487707 (+)
WSB/EiJ	ENSIUOG00005004541	protein coding gene	Chr3:103004190-103014573 (+)

Human Ortholog

WDR77, WD repeat domain 77

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WDR77, WD repeat domain 77
Synonyms

HKMT1069, MEP-50, MEP50, Nbla10071, p44, p44/Mep50
Links

HGNC:29652

NCBI Gene ID: 79084

UniProt: Q9BQA1
Chr Location

1p13.2; chr1:111439890-111449256 (-) GRCh38

MGI Vertebrate Homology

Wdr77 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WDR77
Gene Tree

Wdr77

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References

1 with disease annotations

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Phenotype Summary

15 phenotypes from 2 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Wdr77
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele die prior to E8.5 for unknown reasons. Heterozygotes develop multifocal hyperplasia in the dorsal prostate; however, no prostate tumors are detected up to 12 months of age.

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All GO Annotations

41
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

82
cDNA Data

206
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wdr77

ZFIN wdr77

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All Sequences

56
RefSeq

2
UniProt

4
CCDS

CCDS17715.1

Ensembl

ENSMUSG00000000561 (Evidence)
NCBI Gene

70465

			Length	Strain/Species	Flank
genomic	70465	NCBI Gene Model \| MGI Sequence Detail	10263	C57BL/6J	± kb
transcript	NM_027432	RefSeq \| MGI Sequence Detail	3553	C57BL/6
polypeptide	Q99J09	UniProt \| EBI \| MGI Sequence Detail	342	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017398 methylosome protein WDR77

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR052139 Methylosome Component WDR77

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q99J09 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 207

cDNA 207

Microarray probesets 6

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MGI:1923782, MGI:2140070

Summaries

All 62

Developmental Gene Expression 5

Diseases 1

Gene Ontology 13

Phenotypes 14
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:338972 Li J, et al., WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response. Nat Commun. 2023 Aug 10;14(1):4824

TSS for Wdr77:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31092	Chr3:105866726-105866743 (+)	-79 bp
Tssr31093	Chr3:105866769-105866857 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24