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Wdr77
Gene Detail
 Symbol
Name
ID
Wdr77
WD repeat domain 77
MGI:1917715
Synonyms 2610003I18Rik, 2610312E17Rik, p44/MEP50
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:105959369-105984600 bp, + strand
From VEGA annotation of GRCm38

  25232 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11466  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Wdr77

Human
homologs
Human Homolog WDR77, WD repeat domain 77
NCBI Gene ID 79084
neXtProt AC  NX_Q9BQA1
Human Synonyms  MEP50, MEP-50, Nbla10071, p44, p44/Mep50
Human Chr (Location)  1p13.2; chr1:111439890-111449208 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(8) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele die prior to E8.5 for unknown reasons. Heterozygotes develop multifocal hyperplasia in the dorsal prostate; however, no prostate tumors are detected up to 12 months of age.
 
Interactions
Wdr77 interacts with 348 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process negative regulation of cell proliferation, negative regulation of epithelial cell proliferation involved in prostate gland development, ...
Component cytoplasm, cytosol, ...
Function ligand-dependent nuclear receptor transcription coactivator activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (67)    Tissues (65)    Images (2)
Theiler Stages: 25
Assay TypeResults
RNA in situ 67
cDNA source data(205)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(206) cDNA(206)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000027092 (Evidence)
Ensembl Gene ModelENSMUSG00000000561 (Evidence)
Entrez Gene70465 (Evidence)
UniGene5110
DFCITC1571915, TC1596536
Consensus CDS ProjectCCDS17715.1
International Mouse Knockout Project StatusWdr77
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027092 VEGA Gene Model | MGI Sequence Detail 25232 C57BL/6J ±  kb
transcript OTTMUST00000066993 VEGA | MGI Sequence Detail 3682 Not Applicable 
polypeptide OTTMUSP00000033649 VEGA | MGI Sequence Detail 342 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(344 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000017398 methylosome protein 50
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:196527 Vincent B, et al., Loss of the androgen receptor cofactor p44/WDR77 induces astrogliosis. Mol Cell Biol. 2012 Sep;32(17):3500-12
All references(39)
Other
accession IDs
MGI:1923782, MGI:2140070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory