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Unc13d
Gene Detail
 Symbol
Name
ID
Unc13d
unc-13 homolog D (C. elegans)
MGI:1917700
Synonyms 2610108D09Rik, Jinx, Munc13-4
Feature Type protein coding gene
Genetic Map
Chromosome 11
80.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:116062095-116077961 bp, - strand
From VEGA annotation of GRCm38

  15867 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:26714  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Unc13d

Human
homologs
Human Homolog UNC13D, unc-13 homolog D (C. elegans)
NCBI Gene ID 201294
neXtProt AC  NX_Q70J99
Human Synonyms  FHL3, HLH3, HPLH3, Munc13-4
Human Chr (Location)  17q25.1; chr17:75827225-75844717 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human UNC13D
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous ENU mutant mice are sensitive to infection by mouse cytomegalovirus.
 
Human Diseases Modeled Using Mouse Unc13d (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Unc13d interacts with 152 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process defense response to virus, exocytosis, ...
Component cell, cytoplasm, ...
Function protein binding
External Resources: FuncBase
Expression
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000003687 (Evidence)
Ensembl Gene ModelENSMUSG00000057948 (Evidence)
Entrez Gene70450 (Evidence)
UniGene259460
DFCITC1586667, TC1668641
DoTSDT.40164620, DT.91429532, DT.94350389
NIA Mouse Gene IndexU033639
Consensus CDS ProjectCCDS25656.1
International Mouse Knockout Project StatusUnc13d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003687 VEGA Gene Model | MGI Sequence Detail 15867 C57BL/6J ±  kb
transcript OTTMUST00000007989 VEGA | MGI Sequence Detail 4046 Not Applicable 
polypeptide OTTMUSP00000003882 VEGA | MGI Sequence Detail 1085 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(12) UniProt(4)
Polymorphisms SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR014772 Mammalian uncoordinated homology 13, domain 2
InterPro IPR019558 Mammalian uncoordinated homology 13, subgroup, domain 2
InterPro IPR014770 Munc13 homology 1
Protein Ontology PR:000017089 protein unc-13 homolog D
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211540 Singh RK, et al., Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion. FEBS J. 2013 Feb;280(3):892-903
All references(40)
Disease annotation references (1)
Other
accession IDs
MGI:3626342

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory