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Unc13d
Gene Detail
Symbol

Name
ID
Unc13d
unc-13 homolog D (C. elegans)
MGI:1917700
Synonyms
2610108D09Rik, Jinx, Munc13-4
Feature Type
protein coding gene
Genetic Map
Chromosome 11
80.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:116062095-116077961 bp, - strand
From VEGA annotation of GRCm38

  15867 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:26714  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UNC13D
Gene Tree: Unc13d

Human
homologs
UNC13D, unc-13 homolog D (C. elegans)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 201294
neXtProt AC: NX_Q70J99

Human Synonyms: FHL3, HLH3, HPLH3, Munc13-4

Human Chr (Location): 17q25.1; chr17:75827225-75844717 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human UNC13D

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous ENU mutant mice are sensitive to infection by mouse cytomegalovirus.
 
Human Diseases Modeled in Mice Using Unc13d (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Unc13d interacts with 151 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process defense response to virus, exocytosis, ...
Component cell, cytoplasm, ...
Function protein binding, Rab GTPase binding
External Resources: FuncBase
Expression
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase unc13d    NEW 
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000003687 (Evidence)
Ensembl Gene Model ENSMUSG00000057948 (Evidence)
Entrez Gene 70450 (Evidence)
UniGene 259460
DFCI TC1668641, TC1586667
DoTS DT.91429532, DT.94350389, DT.40164620
NIA Mouse Gene Index U033639
Consensus CDS Project CCDS25656.1
International Mouse Phenotyping Consortium Status Unc13d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003687 VEGA Gene Model | MGI Sequence Detail 15867 C57BL/6J ±  kb
transcript OTTMUST00000007989 VEGA | MGI Sequence Detail 4046 Not Applicable 
polypeptide OTTMUSP00000003882 VEGA | MGI Sequence Detail 1085 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(15) UniProt(4)
Polymorphisms
SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR014772 Mammalian uncoordinated homology 13, domain 2
InterPro IPR019558 Mammalian uncoordinated homology 13, subgroup, domain 2
InterPro IPR014770 Munc13 homology 1
Protein Ontology PR:000017089 protein unc-13 homolog D
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218680 Yang F, et al., Granule cargo release from bone marrow-derived cells sustains cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2014 Nov 15;307(10):H1529-38
All references(40)
Disease annotation references (1)
Other
accession IDs
MGI:3626342

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory