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Cd248
Gene Detail
Symbol

Name
ID
Cd248
CD248 antigen, endosialin
MGI:1917695
Synonyms
2610111G01Rik, Cd164l1, Tem1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:5068078-5070637 bp, + strand
From Ensembl annotation of GRCm38

  2560 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10699  Vertebrate Homology Class
1 human; 1 mouse; 3 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CD248
Protein SuperFamily: CD248 antigen/endosialin
Gene Tree: Cd248

Human
homologs
CD248, CD248 molecule, endosialin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57124
neXtProt AC: NX_Q9HCU0

Human Synonyms: CD164L1, TEM1

Human Chr (Location): 11q13; chr11:66314487-66317044 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display decreased growth of implanted abdominal and intestinal tumors, but have normal wound healing and no gross morphological abnormalities.
 
Interactions
Cd248 interacts with 59 markers (Mir96, Mir98, Mir135b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process anatomical structure regression, cell migration, ...
Component cytoplasm, extracellular exosome, ...
Function calcium ion binding, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (309)    Tissues (143)    Images (112)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 58
RNA in situ 117
In situ reporter (knock in) 110
RT-PCR 24
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN cd248b    NEW 
Molecular
reagents
All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000056481 (Evidence)
Entrez Gene 70445 (Evidence)
UniGene 29597
DFCI TC1579529
DoTS DT.487984
NIA Mouse Gene Index U038731
Consensus CDS Project CCDS29448.1
International Mouse Phenotyping Consortium Status Cd248
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056481 Ensembl Gene Model | MGI Sequence Detail 2560 C57BL/6J ±  kb
transcript ENSMUST00000070630 Ensembl | MGI Sequence Detail 2560 Not Applicable 
polypeptide ENSMUSP00000070847 Ensembl | MGI Sequence Detail 765 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
Protein Ontology PR:000001346 endosialin
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:199483 Jadeja S, et al., A CNS-specific hypomorphic Pdgfr-beta mutant model of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2013 May;54(5):3569-78
All references(41)
Other
accession IDs
MGI:2147605

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory