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Cd248 Gene Detail
Summary
  • Symbol
    Cd248
  • Name
    CD248 antigen, endosialin
  • Synonyms
    2610111G01Rik, Cd164l1, Tem1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917695
    NCBI Gene: 70445
  • Gene Overview
    MyGene.info: CD248
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5068078-5070637 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.24 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917695
protein coding gene Chr19:5068078-5070640 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024689
protein coding gene Chr19:1995736-1998295 (+)
A/J MGP_AJ_G0024655
protein coding gene Chr19:1892512-1895071 (+)
AKR/J MGP_AKRJ_G0024628
protein coding gene Chr19:1941806-1944365 (+)
BALB/cJ MGP_BALBcJ_G0024655
protein coding gene Chr19:1883016-1885575 (+)
C3H/HeJ MGP_C3HHeJ_G0024423
protein coding gene Chr19:1944471-1947030 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025102
protein coding gene Chr19:2052600-2055159 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022532
protein coding gene Chr19:1821868-1824428 (+)
CAST/EiJ MGP_CASTEiJ_G0023895
protein coding gene Chr19:1969919-1972478 (+)
CBA/J MGP_CBAJ_G0024394
protein coding gene Chr19:2132057-2134616 (+)
DBA/2J MGP_DBA2J_G0024522
protein coding gene Chr19:1877615-1880174 (+)
FVB/NJ MGP_FVBNJ_G0024489
protein coding gene Chr19:1878240-1880799 (+)
LP/J MGP_LPJ_G0024608
protein coding gene Chr19:1990022-1992581 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024519
protein coding gene Chr19:2014914-2017473 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025150
protein coding gene Chr19:1945266-1947825 (+)
PWK/PhJ MGP_PWKPhJ_G0023641
protein coding gene Chr19:1915167-1917726 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023446
protein coding gene Chr19:1932999-1935559 (+)
WSB/EiJ MGP_WSBEiJ_G0023957
protein coding gene Chr19:1949339-1951895 (+)



Homology
more
  • Human Ortholog
    CD248, CD248 molecule
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CD248, CD248 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD164L1, TEM1
  • Links
    NCBI Gene ID: 57124
    neXtProt AC: NX_Q9HCU0
    UniProt: Q9HCU0

  • Chr Location
    11q13.2; chr11:66314487-66317044 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased growth of implanted abdominal and intestinal tumors, but have normal wound healing and no gross morphological abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056481 Ensembl Gene Model | MGI Sequence Detail 2560 C57BL/6J ±  kb
transcript ENSMUST00000070630 Ensembl | MGI Sequence Detail 2560 Not Applicable  
polypeptide ENSMUSP00000070847 Ensembl | MGI Sequence Detail 765 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 27
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2147605
References
more
  • Summaries
    All 47
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265109 Mogler C, et al., Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin. EMBO Mol Med. 2017 Jun;9(6):741-749

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory